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Distribution of osteoarthritis in a Norwegian population-based cohort : associations to risk factor profiles and health-related quality of life

Lombnæs, Guro Økelsrud ; Magnusson, Karin LU ; Østerås, Nina ; Nordsletten, Lars ; Risberg, May Arna and Hagen, Kåre Birger (2017) In Rheumatology International 37(9). p.1541-1550
Abstract

The objective of the study was to examine the hand-, knee- and hip osteoarthritis (OA) distribution, risk factor profiles and health-related quality of life (HRQoL) in a population-based OA cohort. Persons with self-reported OA responded to questionnaires and attended a clinical examination (N = 606). We analyzed cross-sectional associations to risk factor profiles and HRQoL dimensions (Short Form 36) in four mutually exclusive groups based on fulfillment of The American College of Rheumatology criteria: no OA (NOA), monoarticular upper extremity (hand) OA (MOAupper-ex.), monoarticular lower extremity (hip or knee) OA (MOAlower-ex.) and polyarticular OA (POA). Multivariate regression analyses and correspondence analysis were performed.... (More)

The objective of the study was to examine the hand-, knee- and hip osteoarthritis (OA) distribution, risk factor profiles and health-related quality of life (HRQoL) in a population-based OA cohort. Persons with self-reported OA responded to questionnaires and attended a clinical examination (N = 606). We analyzed cross-sectional associations to risk factor profiles and HRQoL dimensions (Short Form 36) in four mutually exclusive groups based on fulfillment of The American College of Rheumatology criteria: no OA (NOA), monoarticular upper extremity (hand) OA (MOAupper-ex.), monoarticular lower extremity (hip or knee) OA (MOAlower-ex.) and polyarticular OA (POA). Multivariate regression analyses and correspondence analysis were performed. The distribution of NOA, MOAupper-ex. MOAlower-ex. and POA was 21.1, 25.4, 22.4 and 31.0%, respectively. Compared to NOA, minor differences were found in risk factor profile in MOAupper-ex., whereas POA was significantly associated with sociodemographic, metabolic and mechanical features. The correspondence analysis identified different risk factor profiles between the four OA phenotypes, but the differences were not statistically significant (p = 0.13). Regarding HRQoL, neither OA groups were associated with poorer mental functioning. MOAlower-ex. and POA were associated with, among other things, poorer physical functioning (β = −6.2, 95% CI −11.2 to −1.2 and β = −12.5, 95% CI −17.4 to −7.9, respectively) and more pain (β = −5.4, 95% CI −10.4 to −0.3 and β = −10.5, 95% CI −15.3 to −5.8, respectively). In this cohort of persons with self-reported OA, POA was the most prevalent phenotype and was associated with an unfortunate risk factor profile and several diminished HRQoL dimensions. POA needs further attention in research and clinical care.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Health-related quality of life, Osteoarthritis, Phenotypes, Risk factor profiles
in
Rheumatology International
volume
37
issue
9
pages
10 pages
publisher
Springer
external identifiers
  • scopus:85018261789
  • pmid:28451795
ISSN
0172-8172
DOI
10.1007/s00296-017-3721-6
language
English
LU publication?
no
id
70ade279-9585-49e9-8bb2-ed4afa60a4be
date added to LUP
2018-11-29 15:18:32
date last changed
2020-04-02 02:13:49
@article{70ade279-9585-49e9-8bb2-ed4afa60a4be,
  abstract     = {<p>The objective of the study was to examine the hand-, knee- and hip osteoarthritis (OA) distribution, risk factor profiles and health-related quality of life (HRQoL) in a population-based OA cohort. Persons with self-reported OA responded to questionnaires and attended a clinical examination (N = 606). We analyzed cross-sectional associations to risk factor profiles and HRQoL dimensions (Short Form 36) in four mutually exclusive groups based on fulfillment of The American College of Rheumatology criteria: no OA (NOA), monoarticular upper extremity (hand) OA (MOAupper-ex.), monoarticular lower extremity (hip or knee) OA (MOAlower-ex.) and polyarticular OA (POA). Multivariate regression analyses and correspondence analysis were performed. The distribution of NOA, MOAupper-ex. MOAlower-ex. and POA was 21.1, 25.4, 22.4 and 31.0%, respectively. Compared to NOA, minor differences were found in risk factor profile in MOAupper-ex., whereas POA was significantly associated with sociodemographic, metabolic and mechanical features. The correspondence analysis identified different risk factor profiles between the four OA phenotypes, but the differences were not statistically significant (p = 0.13). Regarding HRQoL, neither OA groups were associated with poorer mental functioning. MOAlower-ex. and POA were associated with, among other things, poorer physical functioning (β = −6.2, 95% CI −11.2 to −1.2 and β = −12.5, 95% CI −17.4 to −7.9, respectively) and more pain (β = −5.4, 95% CI −10.4 to −0.3 and β = −10.5, 95% CI −15.3 to −5.8, respectively). In this cohort of persons with self-reported OA, POA was the most prevalent phenotype and was associated with an unfortunate risk factor profile and several diminished HRQoL dimensions. POA needs further attention in research and clinical care.</p>},
  author       = {Lombnæs, Guro Økelsrud and Magnusson, Karin and Østerås, Nina and Nordsletten, Lars and Risberg, May Arna and Hagen, Kåre Birger},
  issn         = {0172-8172},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {1541--1550},
  publisher    = {Springer},
  series       = {Rheumatology International},
  title        = {Distribution of osteoarthritis in a Norwegian population-based cohort : associations to risk factor profiles and health-related quality of life},
  url          = {http://dx.doi.org/10.1007/s00296-017-3721-6},
  doi          = {10.1007/s00296-017-3721-6},
  volume       = {37},
  year         = {2017},
}