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Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Borggren, Marie LU ; Repits, Johanna ; Sterjovski, Jasminka ; Uchtenhagen, Hannes ; Churchill, Melissa J ; Karlsson, Anders ; Albert, Jan ; Achour, Adnane ; Gorry, Paul R and Fenyö, Eva Maria LU , et al. (2011) In PLoS ONE 6(6).
Abstract
Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
6
issue
6
article number
e20135
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000291734100005
  • pmid:21698221
  • scopus:79959229025
ISSN
1932-6203
DOI
10.1371/journal.pone.0020135
language
English
LU publication?
yes
id
70cf378e-3896-4b3b-92bd-2a00cd0012af (old id 2007819)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21698221?dopt=Abstract
date added to LUP
2016-04-04 09:18:40
date last changed
2025-10-14 09:06:46
@article{70cf378e-3896-4b3b-92bd-2a00cd0012af,
  abstract     = {{Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.}},
  author       = {{Borggren, Marie and Repits, Johanna and Sterjovski, Jasminka and Uchtenhagen, Hannes and Churchill, Melissa J and Karlsson, Anders and Albert, Jan and Achour, Adnane and Gorry, Paul R and Fenyö, Eva Maria and Jansson, Marianne}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.}},
  url          = {{https://lup.lub.lu.se/search/files/5289400/2172652.pdf}},
  doi          = {{10.1371/journal.pone.0020135}},
  volume       = {{6}},
  year         = {{2011}},
}