Syndecans as receptors and organizers of the extracellular matrix
(2010) In Cell and Tissue Research 339(1). p.31-46- Abstract
Syndecans are type I transmembrane proteins having a core protein modified with glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of molecules, present in invertebrates and vertebrates. Among the plethora of molecules that can interact with heparan sulphate, the collagens and glycoproteins of the extracellular matrix are prominent. Frequently, they do so in conjunction with other receptors, most notably the integrins. For this reason, they are often referred to as "co-receptors". However, just as with integrins, syndecans can interact with actin-associated proteins and signalling molecules, such as protein kinases. Some aspects of syndecan signalling are understood but much remains to be learned. The... (More)
Syndecans are type I transmembrane proteins having a core protein modified with glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of molecules, present in invertebrates and vertebrates. Among the plethora of molecules that can interact with heparan sulphate, the collagens and glycoproteins of the extracellular matrix are prominent. Frequently, they do so in conjunction with other receptors, most notably the integrins. For this reason, they are often referred to as "co-receptors". However, just as with integrins, syndecans can interact with actin-associated proteins and signalling molecules, such as protein kinases. Some aspects of syndecan signalling are understood but much remains to be learned. The functions of syndecans in regulating cell adhesion and extracellular matrix assembly are described here. Evidence from null mice suggests that syndecans have roles in postnatal tissue repair, inflammation and tumour progression. Developmental deficits in lower vertebrates in which syndecans are eliminated are also informative and suggest that, in mammals, redundancy is a key issue.
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- author
- Xian, Xiaojie LU ; Gopal, Sandeep LU and Couchman, John R
- publishing date
- 2010-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Collagen/genetics, Extracellular Matrix/genetics, Heparitin Sulfate/genetics, Humans, Integrins/genetics, Mice, Mice, Mutant Strains, Protein Kinases/genetics, Signal Transduction, Syndecans/genetics
- in
- Cell and Tissue Research
- volume
- 339
- issue
- 1
- pages
- 31 - 46
- publisher
- Springer
- external identifiers
-
- scopus:72449210453
- pmid:19597846
- ISSN
- 1432-0878
- DOI
- 10.1007/s00441-009-0829-3
- language
- English
- LU publication?
- no
- id
- 70dd7c68-c938-4376-b463-45c9580dfb55
- date added to LUP
- 2021-10-25 13:23:32
- date last changed
- 2024-09-08 03:38:54
@article{70dd7c68-c938-4376-b463-45c9580dfb55, abstract = {{<p>Syndecans are type I transmembrane proteins having a core protein modified with glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of molecules, present in invertebrates and vertebrates. Among the plethora of molecules that can interact with heparan sulphate, the collagens and glycoproteins of the extracellular matrix are prominent. Frequently, they do so in conjunction with other receptors, most notably the integrins. For this reason, they are often referred to as "co-receptors". However, just as with integrins, syndecans can interact with actin-associated proteins and signalling molecules, such as protein kinases. Some aspects of syndecan signalling are understood but much remains to be learned. The functions of syndecans in regulating cell adhesion and extracellular matrix assembly are described here. Evidence from null mice suggests that syndecans have roles in postnatal tissue repair, inflammation and tumour progression. Developmental deficits in lower vertebrates in which syndecans are eliminated are also informative and suggest that, in mammals, redundancy is a key issue.</p>}}, author = {{Xian, Xiaojie and Gopal, Sandeep and Couchman, John R}}, issn = {{1432-0878}}, keywords = {{Animals; Collagen/genetics; Extracellular Matrix/genetics; Heparitin Sulfate/genetics; Humans; Integrins/genetics; Mice; Mice, Mutant Strains; Protein Kinases/genetics; Signal Transduction; Syndecans/genetics}}, language = {{eng}}, number = {{1}}, pages = {{31--46}}, publisher = {{Springer}}, series = {{Cell and Tissue Research}}, title = {{Syndecans as receptors and organizers of the extracellular matrix}}, url = {{http://dx.doi.org/10.1007/s00441-009-0829-3}}, doi = {{10.1007/s00441-009-0829-3}}, volume = {{339}}, year = {{2010}}, }