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Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix

Urboniene, Vidita ; Pucetaite, Milda LU ; Jankevicius, Feliksas ; Zelvys, Arunas ; Sablinskas, Valdas and Steiner, Gerald (2014) In Journal of Biomedical Optics 19(8).
Abstract
Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200 cm−1 and around 1750 cm−1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these
bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest... (More)
Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200 cm−1 and around 1750 cm−1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these
bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest that FT-IR spectroscopy of the ECM is an innovative emerging technology for real-time intraoperative tumor diagnosis, which may improve margin clearance in renal cancer surgery. (Less)
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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Journal of Biomedical Optics
volume
19
issue
8
article number
087005
publisher
SPIE
external identifiers
  • scopus:84929503777
ISSN
1083-3668
DOI
10.1117/1.JBO.19.8.087005
language
English
LU publication?
no
id
70e04854-3491-4962-bed7-278e0a540472
date added to LUP
2019-03-26 10:33:30
date last changed
2022-02-15 17:32:17
@article{70e04854-3491-4962-bed7-278e0a540472,
  abstract     = {{Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200 cm−1 and around 1750 cm−1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these<br/>bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest that FT-IR spectroscopy of the ECM is an innovative emerging technology for real-time intraoperative tumor diagnosis, which may improve margin clearance in renal cancer surgery.}},
  author       = {{Urboniene, Vidita and Pucetaite, Milda and Jankevicius, Feliksas and Zelvys, Arunas and Sablinskas, Valdas and Steiner, Gerald}},
  issn         = {{1083-3668}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{SPIE}},
  series       = {{Journal of Biomedical Optics}},
  title        = {{Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix}},
  url          = {{http://dx.doi.org/10.1117/1.JBO.19.8.087005}},
  doi          = {{10.1117/1.JBO.19.8.087005}},
  volume       = {{19}},
  year         = {{2014}},
}