The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion
(1999) In Thrombosis Research 96(4). p.7-323- Abstract
The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A... (More)
The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A mutation nor the platelet glycoprotein IIIa polymorphism PlA2 seem to be associated with central retinal vein occlusion.
(Less)
- author
- Larsson, J and Hillarp, A LU
- organization
- publishing date
- 1999-11-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Antigens, CD/genetics, Blood Platelets/chemistry, Female, Gene Frequency, Genotype, Humans, Integrin beta3, Integrins/genetics, Male, Middle Aged, Platelet Membrane Glycoproteins/genetics, Point Mutation, Polymorphism, Genetic, Prevalence, Prothrombin/genetics, Retinal Vein Occlusion/genetics
- in
- Thrombosis Research
- volume
- 96
- issue
- 4
- pages
- 7 - 323
- publisher
- Elsevier
- external identifiers
-
- scopus:0032743845
- pmid:10593436
- ISSN
- 0049-3848
- DOI
- 10.1016/s0049-3848(99)00111-5
- language
- English
- LU publication?
- yes
- id
- 71056295-60b9-49d2-8536-2a2c283647e1
- date added to LUP
- 2022-08-29 10:26:24
- date last changed
- 2024-01-03 16:17:01
@article{71056295-60b9-49d2-8536-2a2c283647e1, abstract = {{<p>The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A mutation nor the platelet glycoprotein IIIa polymorphism PlA2 seem to be associated with central retinal vein occlusion.</p>}}, author = {{Larsson, J and Hillarp, A}}, issn = {{0049-3848}}, keywords = {{Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Antigens, CD/genetics; Blood Platelets/chemistry; Female; Gene Frequency; Genotype; Humans; Integrin beta3; Integrins/genetics; Male; Middle Aged; Platelet Membrane Glycoproteins/genetics; Point Mutation; Polymorphism, Genetic; Prevalence; Prothrombin/genetics; Retinal Vein Occlusion/genetics}}, language = {{eng}}, month = {{11}}, number = {{4}}, pages = {{7--323}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion}}, url = {{http://dx.doi.org/10.1016/s0049-3848(99)00111-5}}, doi = {{10.1016/s0049-3848(99)00111-5}}, volume = {{96}}, year = {{1999}}, }