Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion

Larsson, J and Hillarp, A LU (1999) In Thrombosis Research 96(4). p.7-323
Abstract

The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A... (More)

The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A mutation nor the platelet glycoprotein IIIa polymorphism PlA2 seem to be associated with central retinal vein occlusion.

(Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Antigens, CD/genetics, Blood Platelets/chemistry, Female, Gene Frequency, Genotype, Humans, Integrin beta3, Integrins/genetics, Male, Middle Aged, Platelet Membrane Glycoproteins/genetics, Point Mutation, Polymorphism, Genetic, Prevalence, Prothrombin/genetics, Retinal Vein Occlusion/genetics
in
Thrombosis Research
volume
96
issue
4
pages
7 - 323
publisher
Elsevier
external identifiers
  • scopus:0032743845
  • pmid:10593436
ISSN
0049-3848
DOI
10.1016/s0049-3848(99)00111-5
language
English
LU publication?
yes
id
71056295-60b9-49d2-8536-2a2c283647e1
date added to LUP
2022-08-29 10:26:24
date last changed
2024-01-03 16:17:01
@article{71056295-60b9-49d2-8536-2a2c283647e1,
  abstract     = {{<p>The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 have been shown to be associated with thromboembolic disease. We wondered if mutations were overrepresented in patients with central retinal vein occlusion. We studied 129 consecutive patients with a history of central retinal vein occlusion. We analysed for the prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 and compared the results to controls with no history of thrombosis. For the platelet glycoprotein IIIa polymorphism PlA2, 69% were normal, 26% were heterozygous, and 5% were homozygous. For the G20210A prothrombin mutation, 97% were normal and 3% were heterozygous. Neither the prothrombin gene G20210A mutation nor the platelet glycoprotein IIIa polymorphism PlA2 seem to be associated with central retinal vein occlusion.</p>}},
  author       = {{Larsson, J and Hillarp, A}},
  issn         = {{0049-3848}},
  keywords     = {{Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Antigens, CD/genetics; Blood Platelets/chemistry; Female; Gene Frequency; Genotype; Humans; Integrin beta3; Integrins/genetics; Male; Middle Aged; Platelet Membrane Glycoproteins/genetics; Point Mutation; Polymorphism, Genetic; Prevalence; Prothrombin/genetics; Retinal Vein Occlusion/genetics}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{4}},
  pages        = {{7--323}},
  publisher    = {{Elsevier}},
  series       = {{Thrombosis Research}},
  title        = {{The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion}},
  url          = {{http://dx.doi.org/10.1016/s0049-3848(99)00111-5}},
  doi          = {{10.1016/s0049-3848(99)00111-5}},
  volume       = {{96}},
  year         = {{1999}},
}