Fibromodulin Regulates Collagen Fibrillogenesis During Peripheral Corneal Development
(2010) In Developmental Dynamics 239(3). p.844-854- Abstract
- Fibromodulin regulates collagen fibrillogenesis, but its existence/role(s) in the cornea is controversial. We hypothesize that fibromodulin regulates fibrillogenesis during postnatal development of the anterior eye. Fibromodulin is weakly expressed in the limbus at post-natal day (P) 4, increases and extends into the central cornea at P14, becomes restricted to the limbus at P30, and decreases at P60. This differential spatial and temporal expression of fibromodulin is coordinated with emmetropization; the developmental increase in axial length and globe size. Genetic analysis demonstrated that fibromodulin regulates fibrillogenesis in a region-specific manner. At the limbus, fibromodulin is dominant in regulating fibril growth during... (More)
- Fibromodulin regulates collagen fibrillogenesis, but its existence/role(s) in the cornea is controversial. We hypothesize that fibromodulin regulates fibrillogenesis during postnatal development of the anterior eye. Fibromodulin is weakly expressed in the limbus at post-natal day (P) 4, increases and extends into the central cornea at P14, becomes restricted to the limbus at P30, and decreases at P60. This differential spatial and temporal expression of fibromodulin is coordinated with emmetropization; the developmental increase in axial length and globe size. Genetic analysis demonstrated that fibromodulin regulates fibrillogenesis in a region-specific manner. At the limbus, fibromodulin is dominant in regulating fibril growth during postnatal development. In the posterior peripheral cornea, cooperative interactions of fibromodulin and lumican regulate fibrillogenesis. These data indicate that fibromodulin plays important roles in the regulation of region-specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis. Developmental Dynamics 239:844-854, 2010 (C) 2010 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1588086
- author
- Chen, Shoujun ; Oldberg, Åke LU ; Chakravarti, Shukti and Birk, David E.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- collagen fibril assembly, limbus, cornea, eye development, proteoglycans, fibromodulin
- in
- Developmental Dynamics
- volume
- 239
- issue
- 3
- pages
- 844 - 854
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000275633100011
- scopus:77149168134
- ISSN
- 1097-0177
- DOI
- 10.1002/dvdy.22216
- language
- English
- LU publication?
- yes
- id
- 710fb1b6-433c-43e5-9dc3-4cf077f1b0c7 (old id 1588086)
- date added to LUP
- 2016-04-01 10:12:34
- date last changed
- 2022-04-27 19:43:36
@article{710fb1b6-433c-43e5-9dc3-4cf077f1b0c7,
abstract = {{Fibromodulin regulates collagen fibrillogenesis, but its existence/role(s) in the cornea is controversial. We hypothesize that fibromodulin regulates fibrillogenesis during postnatal development of the anterior eye. Fibromodulin is weakly expressed in the limbus at post-natal day (P) 4, increases and extends into the central cornea at P14, becomes restricted to the limbus at P30, and decreases at P60. This differential spatial and temporal expression of fibromodulin is coordinated with emmetropization; the developmental increase in axial length and globe size. Genetic analysis demonstrated that fibromodulin regulates fibrillogenesis in a region-specific manner. At the limbus, fibromodulin is dominant in regulating fibril growth during postnatal development. In the posterior peripheral cornea, cooperative interactions of fibromodulin and lumican regulate fibrillogenesis. These data indicate that fibromodulin plays important roles in the regulation of region-specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis. Developmental Dynamics 239:844-854, 2010 (C) 2010 Wiley-Liss, Inc.}},
author = {{Chen, Shoujun and Oldberg, Åke and Chakravarti, Shukti and Birk, David E.}},
issn = {{1097-0177}},
keywords = {{collagen fibril assembly; limbus; cornea; eye development; proteoglycans; fibromodulin}},
language = {{eng}},
number = {{3}},
pages = {{844--854}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Developmental Dynamics}},
title = {{Fibromodulin Regulates Collagen Fibrillogenesis During Peripheral Corneal Development}},
url = {{http://dx.doi.org/10.1002/dvdy.22216}},
doi = {{10.1002/dvdy.22216}},
volume = {{239}},
year = {{2010}},
}