Protective effect of Opuntia ficus-indica L. cladodes against UVA-induced oxidative stress in normal human keratinocytes
Petruk, Ganna LU
; Di Lorenzo, Flaviana
; Imbimbo, Paola
; Silipo, Alba
; Bonina, Andrea
; Rizza, Luisa
; Piccoli, Renata
; Monti, Daria Maria
and Lanzetta, Rosa
(2017)
In Bioorganic and Medicinal Chemistry Letters
27(24).
p.5485-5489
- Abstract
Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear protective effect against UVA-induced stress was evidenced, as indicated by the inhibition of stress-induced processes, such as free radicals production, lipid peroxidation and GSH depletion. Moreover, a clear protective effect against apoptosis in pre-treated irradiated cells was evidenced. We found that eucomic and piscidic acids were... (More)
Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear protective effect against UVA-induced stress was evidenced, as indicated by the inhibition of stress-induced processes, such as free radicals production, lipid peroxidation and GSH depletion. Moreover, a clear protective effect against apoptosis in pre-treated irradiated cells was evidenced. We found that eucomic and piscidic acids were responsible for the anti-oxidative stress action of cladode extract. In conclusion, a bioactive, safe, low-cost and high value-added extract from Opuntia cladodes was obtained to be used for skin health/protection.
(Less)
- author
- Petruk, Ganna
LU
; Di Lorenzo, Flaviana
; Imbimbo, Paola
; Silipo, Alba
; Bonina, Andrea
; Rizza, Luisa
; Piccoli, Renata
; Monti, Daria Maria
and Lanzetta, Rosa
- publishing date
- 2017-12-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Antioxidants, Cladode water extracts, Eucomic acid, Opuntia ficus-indica L., Piscidic acid, UVA-induced oxidative stress
- in
- Bioorganic and Medicinal Chemistry Letters
- volume
- 27
- issue
- 24
- pages
- 5485 - 5489
- publisher
- Elsevier
- external identifiers
-
- scopus:85032262672
- pmid:29107540
- ISSN
- 0960-894X
- DOI
- 10.1016/j.bmcl.2017.10.043
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2017 Elsevier Ltd
- id
- 71111984-6854-4f13-8796-633473ec5cb0
- date added to LUP
- 2025-01-21 15:38:47
- date last changed
- 2025-07-23 06:15:42
@article{71111984-6854-4f13-8796-633473ec5cb0,
abstract = {{<p>Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear protective effect against UVA-induced stress was evidenced, as indicated by the inhibition of stress-induced processes, such as free radicals production, lipid peroxidation and GSH depletion. Moreover, a clear protective effect against apoptosis in pre-treated irradiated cells was evidenced. We found that eucomic and piscidic acids were responsible for the anti-oxidative stress action of cladode extract. In conclusion, a bioactive, safe, low-cost and high value-added extract from Opuntia cladodes was obtained to be used for skin health/protection.</p>}},
author = {{Petruk, Ganna and Di Lorenzo, Flaviana and Imbimbo, Paola and Silipo, Alba and Bonina, Andrea and Rizza, Luisa and Piccoli, Renata and Monti, Daria Maria and Lanzetta, Rosa}},
issn = {{0960-894X}},
keywords = {{Antioxidants; Cladode water extracts; Eucomic acid; Opuntia ficus-indica L.; Piscidic acid; UVA-induced oxidative stress}},
language = {{eng}},
month = {{12}},
number = {{24}},
pages = {{5485--5489}},
publisher = {{Elsevier}},
series = {{Bioorganic and Medicinal Chemistry Letters}},
title = {{Protective effect of Opuntia ficus-indica L. cladodes against UVA-induced oxidative stress in normal human keratinocytes}},
url = {{http://dx.doi.org/10.1016/j.bmcl.2017.10.043}},
doi = {{10.1016/j.bmcl.2017.10.043}},
volume = {{27}},
year = {{2017}},
}