Actin/myosin-based gliding motility in apicomplexan parasites
Matuschewski, Kai and Schüler, Herwig LU
(2008)
In Sub-cellular biochemistry
47.
p.110-120
- Abstract
Apicomplexan parasites move and actively enter host cells by substrate-dependent gliding motility, an unusual form of eukaryotic locomotion that differs fundamentally from the motility of prokaryotic and viral pathogens. Recent research has uncovered some of the cellular and molecular mechanisms underlying parasite motility, transmigration, and cell invasion during life cycle progression. The gliding motor machinery is embedded between the plasma membrane and the inner membrane complex, a unique double membrane layer. It consists ofimmobilized unconventional myosins, short actin stubs, and TRAP-family invasins. Assembly of this motor machinery enables force generation between parasite cytoskeletal components and an extracellular... (More)
Apicomplexan parasites move and actively enter host cells by substrate-dependent gliding motility, an unusual form of eukaryotic locomotion that differs fundamentally from the motility of prokaryotic and viral pathogens. Recent research has uncovered some of the cellular and molecular mechanisms underlying parasite motility, transmigration, and cell invasion during life cycle progression. The gliding motor machinery is embedded between the plasma membrane and the inner membrane complex, a unique double membrane layer. It consists ofimmobilized unconventional myosins, short actin stubs, and TRAP-family invasins. Assembly of this motor machinery enables force generation between parasite cytoskeletal components and an extracellular substratum. Unique properties of the individual components suggest that the rational design of motility inhibitors may lead to new intervention strategies to combat some of the most devastating human and livestock diseases.
(Less)
- author
- Matuschewski, Kai
and Schüler, Herwig
LU
- publishing date
- 2008
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- keywords
- Actins/chemistry, Animals, Apicomplexa/physiology, Cell Movement/physiology, Forecasting, Models, Biological, Molecular Motor Proteins/physiology, Myosins/chemistry, Protozoan Proteins/physiology
- host publication
- Molecular Mechanisms of Parasite Invasion
- series title
- Sub-cellular biochemistry
- editor
- Burleigh, Barbara A. and Soldati-Favre, Dominique
- volume
- 47
- pages
- 11 pages
- publisher
- Springer
- external identifiers
-
- scopus:46249100459
- pmid:18512346
- ISSN
- 0306-0225
- ISBN
- 978-0-387-78266-9
- DOI
- 10.1007/978-0-387-78267-6_9
- language
- English
- LU publication?
- no
- id
- 7143416b-b3bf-4ab9-8509-276a90fbe607
- date added to LUP
- 2024-11-21 18:04:22
- date last changed
- 2025-01-09 03:13:03
@inbook{7143416b-b3bf-4ab9-8509-276a90fbe607,
abstract = {{<p>Apicomplexan parasites move and actively enter host cells by substrate-dependent gliding motility, an unusual form of eukaryotic locomotion that differs fundamentally from the motility of prokaryotic and viral pathogens. Recent research has uncovered some of the cellular and molecular mechanisms underlying parasite motility, transmigration, and cell invasion during life cycle progression. The gliding motor machinery is embedded between the plasma membrane and the inner membrane complex, a unique double membrane layer. It consists ofimmobilized unconventional myosins, short actin stubs, and TRAP-family invasins. Assembly of this motor machinery enables force generation between parasite cytoskeletal components and an extracellular substratum. Unique properties of the individual components suggest that the rational design of motility inhibitors may lead to new intervention strategies to combat some of the most devastating human and livestock diseases.</p>}},
author = {{Matuschewski, Kai and Schüler, Herwig}},
booktitle = {{Molecular Mechanisms of Parasite Invasion}},
editor = {{Burleigh, Barbara A. and Soldati-Favre, Dominique}},
isbn = {{978-0-387-78266-9}},
issn = {{0306-0225}},
keywords = {{Actins/chemistry; Animals; Apicomplexa/physiology; Cell Movement/physiology; Forecasting; Models, Biological; Molecular Motor Proteins/physiology; Myosins/chemistry; Protozoan Proteins/physiology}},
language = {{eng}},
pages = {{110--120}},
publisher = {{Springer}},
series = {{Sub-cellular biochemistry}},
title = {{Actin/myosin-based gliding motility in apicomplexan parasites}},
url = {{http://dx.doi.org/10.1007/978-0-387-78267-6_9}},
doi = {{10.1007/978-0-387-78267-6_9}},
volume = {{47}},
year = {{2008}},
}