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Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

Yu, Lu LU and Somfai, Peter LU (2019) In Angewandte Chemie - International Edition 58(25). p.8551-8555
Abstract

The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
amines, copper, enamines, enantioselectivity, hydroamination
in
Angewandte Chemie - International Edition
volume
58
issue
25
pages
8551 - 8555
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:30990943
  • scopus:85065719860
ISSN
1433-7851
DOI
10.1002/anie.201902642
language
English
LU publication?
yes
id
71c42a33-9da8-4a55-9bc4-a81f5be6266b
date added to LUP
2019-06-17 11:37:23
date last changed
2022-05-23 07:39:09
@article{71c42a33-9da8-4a55-9bc4-a81f5be6266b,
  abstract     = {{<p>The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.</p>}},
  author       = {{Yu, Lu and Somfai, Peter}},
  issn         = {{1433-7851}},
  keywords     = {{amines; copper; enamines; enantioselectivity; hydroamination}},
  language     = {{eng}},
  number       = {{25}},
  pages        = {{8551--8555}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Angewandte Chemie - International Edition}},
  title        = {{Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines}},
  url          = {{http://dx.doi.org/10.1002/anie.201902642}},
  doi          = {{10.1002/anie.201902642}},
  volume       = {{58}},
  year         = {{2019}},
}