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Gonadotropin-releasing hormone agonist against severe aggression in autism

Van Der Weiden, Robin M F ; Helmerhorst, Frans M. and Eriksson, Tomas LU (2016) In BMJ Case Reports 2016.
Abstract

Aggression in patients with autism spectrum disorder (ASD) presents an important therapeutic challenge. Conventional treatment appears to be inadequate in a number of cases. The occurrence of severe aggressive symptoms since the inception of adolescence in a male patient with ASD suggested a hormonal influence by androgens. Conventional treatment with antipsychotic and antiepileptic drugs and benzodiazepines was ineffective. A subcutaneous long-acting gonadotropin-releasing hormone agonist (GnRH agonist) injection was given on a monthly basis resulting in a substantial improvement in his aggressive behaviour and renewed socialisation.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMJ Case Reports
volume
2016
article number
371
publisher
BMJ Publishing Group
external identifiers
  • pmid:27655876
  • scopus:84989182977
ISSN
1757-790X
DOI
10.1136/bcr-2016-216378
language
English
LU publication?
yes
id
720fe333-3e52-408d-b7ce-358934d6ef7d
date added to LUP
2016-11-03 15:42:57
date last changed
2025-01-12 14:20:08
@article{720fe333-3e52-408d-b7ce-358934d6ef7d,
  abstract     = {{<p>Aggression in patients with autism spectrum disorder (ASD) presents an important therapeutic challenge. Conventional treatment appears to be inadequate in a number of cases. The occurrence of severe aggressive symptoms since the inception of adolescence in a male patient with ASD suggested a hormonal influence by androgens. Conventional treatment with antipsychotic and antiepileptic drugs and benzodiazepines was ineffective. A subcutaneous long-acting gonadotropin-releasing hormone agonist (GnRH agonist) injection was given on a monthly basis resulting in a substantial improvement in his aggressive behaviour and renewed socialisation.</p>}},
  author       = {{Van Der Weiden, Robin M F and Helmerhorst, Frans M. and Eriksson, Tomas}},
  issn         = {{1757-790X}},
  language     = {{eng}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Case Reports}},
  title        = {{Gonadotropin-releasing hormone agonist against severe aggression in autism}},
  url          = {{http://dx.doi.org/10.1136/bcr-2016-216378}},
  doi          = {{10.1136/bcr-2016-216378}},
  volume       = {{2016}},
  year         = {{2016}},
}