Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

DNA methylation risk score for type 2 diabetes is associated with gestational diabetes

Linares-Pineda, Teresa M ; Fragoso-Bargas, Nicolas LU ; Picón, María José ; Molina-Vega, Maria ; Jenum, Anne Karen ; Sletner, Line ; Lee-Ødegård, Sindre ; Opsahl, Julia O. ; Moen, Gunn-Helen and Qvigstad, Elisabeth , et al. (2024) In Cardiovascular Diabetology 23.
Abstract

BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.

METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.

RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM:... (More)

BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.

METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.

RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.

CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pregnancy, Female, Humans, Diabetes, Gestational/diagnosis, DNA Methylation, Diabetes Mellitus, Type 2/diagnosis, Epigenesis, Genetic, Risk Factors
in
Cardiovascular Diabetology
volume
23
article number
68
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85185131280
  • pmid:38350951
ISSN
1475-2840
DOI
10.1186/s12933-024-02151-z
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
722cc279-3c38-4fcc-946a-34b6795de576
date added to LUP
2024-02-22 12:00:21
date last changed
2024-04-22 14:10:08
@article{722cc279-3c38-4fcc-946a-34b6795de576,
  abstract     = {{<p>BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.</p><p>METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.</p><p>RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.</p><p>CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.</p>}},
  author       = {{Linares-Pineda, Teresa M and Fragoso-Bargas, Nicolas and Picón, María José and Molina-Vega, Maria and Jenum, Anne Karen and Sletner, Line and Lee-Ødegård, Sindre and Opsahl, Julia O. and Moen, Gunn-Helen and Qvigstad, Elisabeth and Prasad, Rashmi B and Birkeland, Kåre I and Morcillo, Sonsoles and Sommer, Christine}},
  issn         = {{1475-2840}},
  keywords     = {{Pregnancy; Female; Humans; Diabetes, Gestational/diagnosis; DNA Methylation; Diabetes Mellitus, Type 2/diagnosis; Epigenesis, Genetic; Risk Factors}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Cardiovascular Diabetology}},
  title        = {{DNA methylation risk score for type 2 diabetes is associated with gestational diabetes}},
  url          = {{http://dx.doi.org/10.1186/s12933-024-02151-z}},
  doi          = {{10.1186/s12933-024-02151-z}},
  volume       = {{23}},
  year         = {{2024}},
}