DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
(2024) In Cardiovascular Diabetology 23.- Abstract
BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.
METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.
RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM:... (More)
BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.
METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.
RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.
CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.
(Less)
- author
- organization
- publishing date
- 2024-02-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pregnancy, Female, Humans, Diabetes, Gestational/diagnosis, DNA Methylation, Diabetes Mellitus, Type 2/diagnosis, Epigenesis, Genetic, Risk Factors
- in
- Cardiovascular Diabetology
- volume
- 23
- article number
- 68
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:38350951
- scopus:85185131280
- ISSN
- 1475-2840
- DOI
- 10.1186/s12933-024-02151-z
- language
- English
- LU publication?
- yes
- additional info
- © 2024. The Author(s).
- id
- 722cc279-3c38-4fcc-946a-34b6795de576
- date added to LUP
- 2024-02-22 12:00:21
- date last changed
- 2025-05-08 08:26:20
@article{722cc279-3c38-4fcc-946a-34b6795de576,
abstract = {{<p>BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.</p><p>METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.</p><p>RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.</p><p>CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.</p>}},
author = {{Linares-Pineda, Teresa M and Fragoso-Bargas, Nicolas and Picón, María José and Molina-Vega, Maria and Jenum, Anne Karen and Sletner, Line and Lee-Ødegård, Sindre and Opsahl, Julia O. and Moen, Gunn-Helen and Qvigstad, Elisabeth and Prasad, Rashmi B and Birkeland, Kåre I and Morcillo, Sonsoles and Sommer, Christine}},
issn = {{1475-2840}},
keywords = {{Pregnancy; Female; Humans; Diabetes, Gestational/diagnosis; DNA Methylation; Diabetes Mellitus, Type 2/diagnosis; Epigenesis, Genetic; Risk Factors}},
language = {{eng}},
month = {{02}},
publisher = {{BioMed Central (BMC)}},
series = {{Cardiovascular Diabetology}},
title = {{DNA methylation risk score for type 2 diabetes is associated with gestational diabetes}},
url = {{http://dx.doi.org/10.1186/s12933-024-02151-z}},
doi = {{10.1186/s12933-024-02151-z}},
volume = {{23}},
year = {{2024}},
}