Host-pathogen interactions in mycobacterial infection – Mechanisms of immunopathology and inflammation
(2025) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases globally. Despite extensive research, many aspects of M. tuberculosis pathogenesis and host immune responses remain unclear, complicating the development of effective treatments. Animal models are crucial for studying these interactions, and Mycobacterium marinum infection in mice serves a valuable surrogate system due to its genetic and pathogenic similarities to M. tuberculosis.
This thesis utilizes the murine M. marinum infection model to investigate host immune responses to mycobacterial infection, with a particular focus on the role of the ESX-1 type VII secretion system. ESX-1 is a key virulence determinant that modulates immune... (More) - Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases globally. Despite extensive research, many aspects of M. tuberculosis pathogenesis and host immune responses remain unclear, complicating the development of effective treatments. Animal models are crucial for studying these interactions, and Mycobacterium marinum infection in mice serves a valuable surrogate system due to its genetic and pathogenic similarities to M. tuberculosis.
This thesis utilizes the murine M. marinum infection model to investigate host immune responses to mycobacterial infection, with a particular focus on the role of the ESX-1 type VII secretion system. ESX-1 is a key virulence determinant that modulates immune cell recruitment and granuloma formation, ultimately shaping disease progression.
The findings presented in this thesis provide new insight into mycobacterial persistence and pathology, particularly the role of ESX-1 in shaping immune responses. Additionally, this works highlights the functions of neutrophils and monocytes in the immune defense. By exploring their dynamic interactions and contributions to inflammation and bacterial control, this research enhances our understanding of host-pathogen interactions in mycobacterial pathogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/72971ad1-3f9d-45ab-9204-94c197fe217b
- author
- Munke, Kristina LU
- supervisor
- opponent
-
- professor Lerm, Maria, Linköpings universitet
- organization
- publishing date
- 2025
- type
- Thesis
- publication status
- published
- subject
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2025:76
- pages
- 67 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Segerfalksalen, BMC A10, Sölvegatan 17 i Lund
- defense date
- 2025-10-03 13:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-729-3
- language
- English
- LU publication?
- yes
- id
- 72971ad1-3f9d-45ab-9204-94c197fe217b
- date added to LUP
- 2025-09-11 13:09:48
- date last changed
- 2025-09-17 12:34:19
@phdthesis{72971ad1-3f9d-45ab-9204-94c197fe217b, abstract = {{Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases globally. Despite extensive research, many aspects of M. tuberculosis pathogenesis and host immune responses remain unclear, complicating the development of effective treatments. Animal models are crucial for studying these interactions, and Mycobacterium marinum infection in mice serves a valuable surrogate system due to its genetic and pathogenic similarities to M. tuberculosis. <br/>This thesis utilizes the murine M. marinum infection model to investigate host immune responses to mycobacterial infection, with a particular focus on the role of the ESX-1 type VII secretion system. ESX-1 is a key virulence determinant that modulates immune cell recruitment and granuloma formation, ultimately shaping disease progression.<br/>The findings presented in this thesis provide new insight into mycobacterial persistence and pathology, particularly the role of ESX-1 in shaping immune responses. Additionally, this works highlights the functions of neutrophils and monocytes in the immune defense. By exploring their dynamic interactions and contributions to inflammation and bacterial control, this research enhances our understanding of host-pathogen interactions in mycobacterial pathogenesis.}}, author = {{Munke, Kristina}}, isbn = {{978-91-8021-729-3}}, issn = {{1652-8220}}, language = {{eng}}, number = {{2025:76}}, publisher = {{Lund University, Faculty of Medicine}}, school = {{Lund University}}, series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}}, title = {{Host-pathogen interactions in mycobacterial infection – Mechanisms of immunopathology and inflammation}}, url = {{https://lup.lub.lu.se/search/files/227465893/Avhandling_Kristina_Munke_LUCRIS.pdf}}, year = {{2025}}, }