Matrix Metalloproteinase-8 Activity is Increased in Type 1 Diabetes Children with High-Risk Diabetes HLA and Systemic Inflammation
(2012) 46th Annual Meeting of the Association for European Paediatric and Congenital Cardiology In Cardiology in the Young 22(S1). p.115-116- Abstract
- Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate... (More)
- Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate (cGMP), along with degree of exposure to secondhand tobacco smoke (STS) were determined in 74 children and adolescents with type 1 diabetes at baseline and 1 year later. MMP-8 and MPO levels were measured only at the 2nd time-point. Results: In univariate regression, baseline BMI, HbA1c, CRP(log), and TC/HDL were all predictors of 1-year MMP-2 (p,.05 for all), while exposure to STS, BMI, cGMP, and TC/ HDL predicted levels of MPO (p,.05 for all). The rise in serum MMP-8 was most increased in those with both DQ2/8 and CRP .1 mg/l (p=0.01), but no such difference was noted with regard to MPO. Conclusion: In young patients with type 1 diabetes, increased activities of MMP and MPO appear to relate mainly to dyslipidemia, but inflammation, particularly in those with diabetes-risk HLA, and exposure to tobacco smoke could be important stimuli as well. (Less)
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https://lup.lub.lu.se/record/72e70fa3-c425-4fda-9838-22b53ec4bce7
- author
- Liuba, P. LU ; Odermarsky, M. LU ; Pussinen, P. ; Sorsa, T. and Maxedius, A. LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neutrophil collagenase, lipid, hemoglobin A1c, cyclic GMP, matrix metalloproteinase, myeloperoxidase, tobacco smoke, high density lipoprotein, gelatinase A, insulin dependent diabetes mellitus, child, human, risk, diabetes mellitus, HLA system, inflammation, cardiology, Japanese (people), society, pediatric cardiology, heart surgery, exposure, adolescent, atherosclerosis, blood pressure, population, precursor, dyslipidemia, cross-sectional study, patient, serum, stimulus, vascular disease, macrophage, passive smoking
- in
- Cardiology in the Young
- volume
- 22
- issue
- S1
- article number
- P170
- pages
- 2 pages
- publisher
- Cambridge University Press
- conference name
- 46th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
- conference location
- Istanbul, Turkey
- conference dates
- 2012-05-23 - 2012-05-26
- ISSN
- 1467-1107
- DOI
- 10.1017/S1047951112000509
- language
- English
- LU publication?
- yes
- id
- 72e70fa3-c425-4fda-9838-22b53ec4bce7
- alternative location
- http://www.uni-kiel.de/aepc/2012/aepcAbstractsFinalPrint/P_170fin.pdf#zoom=100,180,80&toolbar=0&pagemode=none&navpanes=0
- date added to LUP
- 2016-05-04 05:24:49
- date last changed
- 2018-11-21 21:37:57
@misc{72e70fa3-c425-4fda-9838-22b53ec4bce7, abstract = {{Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly in an inflammatory milieu, to peripheral vascular dysfunction, an important precursor of atherosclerosis. In the same population, we aimed to assess whether this putative interplay between DQ2/8 and inflammation also reflects into increased activity of MMP and MPO. Methods: Blood pressure, inflammatory, lipid, HbA1c, cyclic guanilate monophospate (cGMP), along with degree of exposure to secondhand tobacco smoke (STS) were determined in 74 children and adolescents with type 1 diabetes at baseline and 1 year later. MMP-8 and MPO levels were measured only at the 2nd time-point. Results: In univariate regression, baseline BMI, HbA1c, CRP(log), and TC/HDL were all predictors of 1-year MMP-2 (p,.05 for all), while exposure to STS, BMI, cGMP, and TC/ HDL predicted levels of MPO (p,.05 for all). The rise in serum MMP-8 was most increased in those with both DQ2/8 and CRP .1 mg/l (p=0.01), but no such difference was noted with regard to MPO. Conclusion: In young patients with type 1 diabetes, increased activities of MMP and MPO appear to relate mainly to dyslipidemia, but inflammation, particularly in those with diabetes-risk HLA, and exposure to tobacco smoke could be important stimuli as well.}}, author = {{Liuba, P. and Odermarsky, M. and Pussinen, P. and Sorsa, T. and Maxedius, A.}}, issn = {{1467-1107}}, keywords = {{neutrophil collagenase; lipid; hemoglobin A1c; cyclic GMP; matrix metalloproteinase; myeloperoxidase; tobacco smoke; high density lipoprotein; gelatinase A; insulin dependent diabetes mellitus; child; human; risk; diabetes mellitus; HLA system; inflammation; cardiology; Japanese (people); society; pediatric cardiology; heart surgery; exposure; adolescent; atherosclerosis; blood pressure; population; precursor; dyslipidemia; cross-sectional study; patient; serum; stimulus; vascular disease; macrophage; passive smoking}}, language = {{eng}}, note = {{Conference Abstract}}, number = {{S1}}, pages = {{115--116}}, publisher = {{Cambridge University Press}}, series = {{Cardiology in the Young}}, title = {{Matrix Metalloproteinase-8 Activity is Increased in Type 1 Diabetes Children with High-Risk Diabetes HLA and Systemic Inflammation}}, url = {{http://dx.doi.org/10.1017/S1047951112000509}}, doi = {{10.1017/S1047951112000509}}, volume = {{22}}, year = {{2012}}, }