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Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae

Bergmann, Simone; Agarwal, Vaibhav LU and Hammerschmidt, Sven (2015) p.347-362
Abstract

The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent modulators of complex host signaling pathways. These pneumococcal surface proteins either directly mediate adhesion of pneumococci to specific cell surface receptors or recruit extracellular matrix or serum components as molecular bridges for binding to cellular receptors. In turn, adhesion triggers and subverts host signal transduction cascades to promote pneumococcal translocation across tissue barriers and dissemination within host tissues. This chapter summarizes the current knowledge of... (More)

The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent modulators of complex host signaling pathways. These pneumococcal surface proteins either directly mediate adhesion of pneumococci to specific cell surface receptors or recruit extracellular matrix or serum components as molecular bridges for binding to cellular receptors. In turn, adhesion triggers and subverts host signal transduction cascades to promote pneumococcal translocation across tissue barriers and dissemination within host tissues. This chapter summarizes the current knowledge of how pneumolysin and major adhesins manipulate host signaling pathways. The chapter will provide a structured overview of the signaling profiles induced by pneumococci, focusing on the receptors required and comparing the key signaling molecules and intracellular responses involved.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Adhesion, Extracellular matrix, Integrin, Pneumolysin, Signal transduction, Streptococcus pneumoniae, Surface protein
host publication
Streptococcus Pneumoniae
pages
16 pages
publisher
Elsevier Inc.
external identifiers
  • scopus:85054120071
ISBN
9780124105300
9780124114531
DOI
10.1016/B978-0-12-410530-0.00018-1
language
English
LU publication?
yes
id
72ede1b9-cf2c-4765-a51a-df87329401e9
date added to LUP
2018-10-31 13:14:02
date last changed
2019-02-20 11:34:12
@inbook{72ede1b9-cf2c-4765-a51a-df87329401e9,
  abstract     = {<p>The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent modulators of complex host signaling pathways. These pneumococcal surface proteins either directly mediate adhesion of pneumococci to specific cell surface receptors or recruit extracellular matrix or serum components as molecular bridges for binding to cellular receptors. In turn, adhesion triggers and subverts host signal transduction cascades to promote pneumococcal translocation across tissue barriers and dissemination within host tissues. This chapter summarizes the current knowledge of how pneumolysin and major adhesins manipulate host signaling pathways. The chapter will provide a structured overview of the signaling profiles induced by pneumococci, focusing on the receptors required and comparing the key signaling molecules and intracellular responses involved.</p>},
  author       = {Bergmann, Simone and Agarwal, Vaibhav and Hammerschmidt, Sven},
  isbn         = {9780124105300},
  keyword      = {Adhesion,Extracellular matrix,Integrin,Pneumolysin,Signal transduction,Streptococcus pneumoniae,Surface protein},
  language     = {eng},
  month        = {05},
  pages        = {347--362},
  publisher    = {Elsevier Inc.},
  title        = {Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae},
  url          = {http://dx.doi.org/10.1016/B978-0-12-410530-0.00018-1},
  year         = {2015},
}