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Tobacco use, body mass index and the risk of malignant lymphomas--a nationwide cohort study in Sweden

Fernberg, Pia ; Odenbro, Asa LU orcid ; Bellocco, Rino ; Boffetta, Paolo ; Pawitan, Yudi and Adami, Johanna (2006) In International Journal of Cancer 118(9). p.2298-2302
Abstract

In the search for risk factors involved in the etiology of lymphoproliferative malignancies there is still inconsistent evidence regarding effects of smoking tobacco, and the role of smokeless tobacco is poorly investigated. New evidence indicates that excess body weight increases the risk of NHL and HD. To determine if tobacco use of various forms and high Body Mass Index (BMI) affect the occurrence of these neoplasms, we conducted a prospective cohort study on over 330,000 Swedish construction workers included in the Construction Industry Working Environment and Health program. Information on smoking, snuff dipping, height and weight was gathered by self administered questionnaires together with personal interviews. Cancer incidence... (More)

In the search for risk factors involved in the etiology of lymphoproliferative malignancies there is still inconsistent evidence regarding effects of smoking tobacco, and the role of smokeless tobacco is poorly investigated. New evidence indicates that excess body weight increases the risk of NHL and HD. To determine if tobacco use of various forms and high Body Mass Index (BMI) affect the occurrence of these neoplasms, we conducted a prospective cohort study on over 330,000 Swedish construction workers included in the Construction Industry Working Environment and Health program. Information on smoking, snuff dipping, height and weight was gathered by self administered questionnaires together with personal interviews. Cancer incidence was ascertained through the year 2000 by record linkage to the nationwide Swedish Cancer Registry, Migration Registry and Cause of Death Registry. At the end of follow up, 1,309 subjects had been diagnosed with NHL (including chronic lymphocytic leukemia) and 205 with HD respectively. Age adjusted incidence rate ratios were computed using Cox proportional Hazard regression modeling. Smoking cigarette, pipe or cigar was not associated with NHL or HD. There was no evidence indicating a relation between quantity and duration of smoking and NHL or HD risk. No link was found between NHL and usage of smokeless tobacco. Having a BMI of 30 or higher did not convey excess risk of developing NHL or HD compared to normal weight (BMI 18.6-24.9). We conclude that tobacco smoking and high BMI do not entail an increased risk of NHL and HD. Our findings of a relation between the duration of snuff dipping and HD need further investigation.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Female, Hodgkin Disease/epidemiology, Humans, Incidence, Lymphoma, Non-Hodgkin/epidemiology, Male, Middle Aged, Registries/statistics & numerical data, Risk Factors, Smoking/adverse effects, Sweden/epidemiology
in
International Journal of Cancer
volume
118
issue
9
pages
2298 - 2302
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:16331621
  • scopus:33645683300
ISSN
0020-7136
DOI
10.1002/ijc.21617
language
English
LU publication?
no
additional info
2005 Wiley-Liss, Inc.
id
7319e6a7-a6fb-4851-9696-6481e8bc932d
date added to LUP
2020-11-16 10:02:09
date last changed
2024-03-05 14:45:56
@article{7319e6a7-a6fb-4851-9696-6481e8bc932d,
  abstract     = {{<p>In the search for risk factors involved in the etiology of lymphoproliferative malignancies there is still inconsistent evidence regarding effects of smoking tobacco, and the role of smokeless tobacco is poorly investigated. New evidence indicates that excess body weight increases the risk of NHL and HD. To determine if tobacco use of various forms and high Body Mass Index (BMI) affect the occurrence of these neoplasms, we conducted a prospective cohort study on over 330,000 Swedish construction workers included in the Construction Industry Working Environment and Health program. Information on smoking, snuff dipping, height and weight was gathered by self administered questionnaires together with personal interviews. Cancer incidence was ascertained through the year 2000 by record linkage to the nationwide Swedish Cancer Registry, Migration Registry and Cause of Death Registry. At the end of follow up, 1,309 subjects had been diagnosed with NHL (including chronic lymphocytic leukemia) and 205 with HD respectively. Age adjusted incidence rate ratios were computed using Cox proportional Hazard regression modeling. Smoking cigarette, pipe or cigar was not associated with NHL or HD. There was no evidence indicating a relation between quantity and duration of smoking and NHL or HD risk. No link was found between NHL and usage of smokeless tobacco. Having a BMI of 30 or higher did not convey excess risk of developing NHL or HD compared to normal weight (BMI 18.6-24.9). We conclude that tobacco smoking and high BMI do not entail an increased risk of NHL and HD. Our findings of a relation between the duration of snuff dipping and HD need further investigation.</p>}},
  author       = {{Fernberg, Pia and Odenbro, Asa and Bellocco, Rino and Boffetta, Paolo and Pawitan, Yudi and Adami, Johanna}},
  issn         = {{0020-7136}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Body Mass Index; Cohort Studies; Female; Hodgkin Disease/epidemiology; Humans; Incidence; Lymphoma, Non-Hodgkin/epidemiology; Male; Middle Aged; Registries/statistics & numerical data; Risk Factors; Smoking/adverse effects; Sweden/epidemiology}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{9}},
  pages        = {{2298--2302}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Tobacco use, body mass index and the risk of malignant lymphomas--a nationwide cohort study in Sweden}},
  url          = {{http://dx.doi.org/10.1002/ijc.21617}},
  doi          = {{10.1002/ijc.21617}},
  volume       = {{118}},
  year         = {{2006}},
}