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Shifts in Gene Expression Variability in the blood-stage of Plasmodium relictum

Kalbskopf, Victor LU ; Ahrén, Dag LU orcid ; Valkiūnas, Gediminas ; Palinauskas, Vaidas and Hellgren, Olof LU (2021) In Gene 792.
Abstract

Avian malaria is a common and widespread disease of birds caused by a diverse group of pathogens of the genera Plasmodium. We investigated the transcriptomal profiles of one of the most common species, Plasmodium relictum, lineage SGS1, at multiple timepoints during the blood stages of the infection under experimental settings. The parasite showed well separated overall transcriptome profiles between day 8 and 20 after the infection, shown by well separated PCA profiles. Moreover, gene expression becomes more heterogenous within the experimental group late in the infection, either due to adaptations to individual differences between the experimental hosts, or due to desynchronisation of the life-cycle of the parasite. Overall, this... (More)

Avian malaria is a common and widespread disease of birds caused by a diverse group of pathogens of the genera Plasmodium. We investigated the transcriptomal profiles of one of the most common species, Plasmodium relictum, lineage SGS1, at multiple timepoints during the blood stages of the infection under experimental settings. The parasite showed well separated overall transcriptome profiles between day 8 and 20 after the infection, shown by well separated PCA profiles. Moreover, gene expression becomes more heterogenous within the experimental group late in the infection, either due to adaptations to individual differences between the experimental hosts, or due to desynchronisation of the life-cycle of the parasite. Overall, this study shows how the avian malaria system can be used to study gene expression of the avian Plasmodium parasite under controlled experimental settings, thus allowing for future comparative analysis of gene responses of parasite with different life-history traits and host effects.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gene
volume
792
article number
145723
publisher
Elsevier
external identifiers
  • scopus:85107702733
  • pmid:34019936
ISSN
0378-1119
DOI
10.1016/j.gene.2021.145723
language
English
LU publication?
yes
id
737b95b5-6c7d-4b7f-97d4-e8c0226bf482
date added to LUP
2021-05-24 08:51:07
date last changed
2024-03-23 05:02:51
@article{737b95b5-6c7d-4b7f-97d4-e8c0226bf482,
  abstract     = {{<p>Avian malaria is a common and widespread disease of birds caused by a diverse group of pathogens of the genera Plasmodium. We investigated the transcriptomal profiles of one of the most common species, Plasmodium relictum, lineage SGS1, at multiple timepoints during the blood stages of the infection under experimental settings. The parasite showed well separated overall transcriptome profiles between day 8 and 20 after the infection, shown by well separated PCA profiles. Moreover, gene expression becomes more heterogenous within the experimental group late in the infection, either due to adaptations to individual differences between the experimental hosts, or due to desynchronisation of the life-cycle of the parasite. Overall, this study shows how the avian malaria system can be used to study gene expression of the avian Plasmodium parasite under controlled experimental settings, thus allowing for future comparative analysis of gene responses of parasite with different life-history traits and host effects.</p>}},
  author       = {{Kalbskopf, Victor and Ahrén, Dag and Valkiūnas, Gediminas and Palinauskas, Vaidas and Hellgren, Olof}},
  issn         = {{0378-1119}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{Elsevier}},
  series       = {{Gene}},
  title        = {{Shifts in Gene Expression Variability in the blood-stage of Plasmodium relictum}},
  url          = {{http://dx.doi.org/10.1016/j.gene.2021.145723}},
  doi          = {{10.1016/j.gene.2021.145723}},
  volume       = {{792}},
  year         = {{2021}},
}