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Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease

Owens-Walton, Conor ; Jakabek, David ; Power, Brian D. ; Walterfang, Mark ; Velakoulis, Dennis ; Van Westen, Danielle LU ; Looi, Jeffrey C.L. ; Shaw, Marnie and Hansson, Oskar LU (2019) In PLoS ONE 14(9).
Abstract

Parkinson’s disease (PD) affects 2–3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with... (More)

Parkinson’s disease (PD) affects 2–3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
14
issue
9
article number
e0222002
publisher
Public Library of Science
external identifiers
  • scopus:85071736064
  • pmid:31483847
ISSN
1932-6203
DOI
10.1371/journal.pone.0222002
language
English
LU publication?
yes
id
73a86080-6252-4d9a-a0bc-9fe163bb6fd1
date added to LUP
2019-09-23 14:30:51
date last changed
2020-10-27 01:29:29
@article{73a86080-6252-4d9a-a0bc-9fe163bb6fd1,
  abstract     = {<p>Parkinson’s disease (PD) affects 2–3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry.</p>},
  author       = {Owens-Walton, Conor and Jakabek, David and Power, Brian D. and Walterfang, Mark and Velakoulis, Dennis and Van Westen, Danielle and Looi, Jeffrey C.L. and Shaw, Marnie and Hansson, Oskar},
  issn         = {1932-6203},
  language     = {eng},
  number       = {9},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease},
  url          = {http://dx.doi.org/10.1371/journal.pone.0222002},
  doi          = {10.1371/journal.pone.0222002},
  volume       = {14},
  year         = {2019},
}