Pharmacokinetics of terlipressin after single i.v. doses to healthy volunteers.
Nilsson, G. ; Lindblom, P ; Ohlin, Mats LU
; Berling, R
and Vernersson, E
(1990)
In Drugs under Experimental and Clinical Research
16(6).
p.307-314
- Abstract
- The pharmacokinetics of triglycyl-lysine-vasopressin (TGLVP) were studied in healthy male volunteers after single i.v. injections of 5, 10 and 20 micrograms/kg b. wt. The half-life of distribution and elimination was 8 and 50 min, respectively. The volume of distribution was 0.7 l/kg b.wt. and the plasma clearance 9 ml/kg b.wt./min. These values are different from those for arginine-vasopressin and lysine-vasopressin (LVP) but confirm to some extent earlier results on TGLVP. No dose-dependent changes of the pharmacokinetics of TGLVP were evident. The LVP formation after TGLVP is described in principle using a combination of pharmacokinetic and pharmacodynamic data. Therapeutically the results in this study suggest a 4-hour interval between... (More)
- The pharmacokinetics of triglycyl-lysine-vasopressin (TGLVP) were studied in healthy male volunteers after single i.v. injections of 5, 10 and 20 micrograms/kg b. wt. The half-life of distribution and elimination was 8 and 50 min, respectively. The volume of distribution was 0.7 l/kg b.wt. and the plasma clearance 9 ml/kg b.wt./min. These values are different from those for arginine-vasopressin and lysine-vasopressin (LVP) but confirm to some extent earlier results on TGLVP. No dose-dependent changes of the pharmacokinetics of TGLVP were evident. The LVP formation after TGLVP is described in principle using a combination of pharmacokinetic and pharmacodynamic data. Therapeutically the results in this study suggest a 4-hour interval between injections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/73b62fad-b468-456a-bcd0-59ebe1c5582d
- author
- Nilsson, G.
; Lindblom, P
; Ohlin, Mats
LU
; Berling, R
and Vernersson, E
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drugs under Experimental and Clinical Research
- volume
- 16
- issue
- 6
- pages
- 307 - 314
- publisher
- Bioscience Ediprint Inc.
- external identifiers
-
- scopus:0025641286
- ISSN
- 0378-6501
- language
- English
- LU publication?
- no
- id
- 73b62fad-b468-456a-bcd0-59ebe1c5582d
- date added to LUP
- 2022-12-05 08:32:20
- date last changed
- 2023-02-08 04:00:19
@article{73b62fad-b468-456a-bcd0-59ebe1c5582d,
abstract = {{The pharmacokinetics of triglycyl-lysine-vasopressin (TGLVP) were studied in healthy male volunteers after single i.v. injections of 5, 10 and 20 micrograms/kg b. wt. The half-life of distribution and elimination was 8 and 50 min, respectively. The volume of distribution was 0.7 l/kg b.wt. and the plasma clearance 9 ml/kg b.wt./min. These values are different from those for arginine-vasopressin and lysine-vasopressin (LVP) but confirm to some extent earlier results on TGLVP. No dose-dependent changes of the pharmacokinetics of TGLVP were evident. The LVP formation after TGLVP is described in principle using a combination of pharmacokinetic and pharmacodynamic data. Therapeutically the results in this study suggest a 4-hour interval between injections.}},
author = {{Nilsson, G. and Lindblom, P and Ohlin, Mats and Berling, R and Vernersson, E}},
issn = {{0378-6501}},
language = {{eng}},
number = {{6}},
pages = {{307--314}},
publisher = {{Bioscience Ediprint Inc.}},
series = {{Drugs under Experimental and Clinical Research}},
title = {{Pharmacokinetics of terlipressin after single i.v. doses to healthy volunteers.}},
volume = {{16}},
year = {{1990}},
}