Advanced

Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa

Sand, Lars Peter; Jalouli, Jamshid; Larsson, Per-Anders LU and Hirsch, Jan-Michael (2002) In Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 93(5). p.92-586
Abstract

OBJECTIVE: The Epstein-Barr virus (EBV) is associated with both malignant and benign diseases in the head and neck region. In several studies it has also been associated with oral squamous cell carcinoma (OSCC). Oral lichen planus (OLP) is a disease with unknown origin, and viral antigens have been proposed as etiologic agents. Smoking and alcohol habits are known risk factors for oral cancer development. In this study, the prevalence of EBV in OSCC and OLP was investigated, along with the effect of smoking, alcohol use, and age on EBV prevalence.

STUDY DESIGN: We examined 29 patients with OSCC, 23 with OLP, and 67 with clinically healthy oral mucosa. For EBV DNA analysis, a nested polymerase chain reaction method was... (More)

OBJECTIVE: The Epstein-Barr virus (EBV) is associated with both malignant and benign diseases in the head and neck region. In several studies it has also been associated with oral squamous cell carcinoma (OSCC). Oral lichen planus (OLP) is a disease with unknown origin, and viral antigens have been proposed as etiologic agents. Smoking and alcohol habits are known risk factors for oral cancer development. In this study, the prevalence of EBV in OSCC and OLP was investigated, along with the effect of smoking, alcohol use, and age on EBV prevalence.

STUDY DESIGN: We examined 29 patients with OSCC, 23 with OLP, and 67 with clinically healthy oral mucosa. For EBV DNA analysis, a nested polymerase chain reaction method was used.

RESULTS: The overall EBV prevalence in patients with oral disease was 32.1%. Of the OSCC patients, 37.9% were EBV positive; and of the OLP patients, 26.1% were EBV positive. Both percentages were statistically significant compared with that of control patients (7.3%). The difference in EBV prevalence between the smoking control group and the nonsmoking control group was insignificant. Increased age did not enhance EBV prevalence.

CONCLUSIONS: This investigation shows that EBV is present in oral diseases such as OSCC and OLP. Smoking, alcohol use, or age does not seem to be a risk factor for EBV infection. The etiologic role of EBV in OSCC and OLP needs to be examined in a prospective follow-up study.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, Carcinoma, Squamous Cell, Case-Control Studies, Cocarcinogenesis, DNA, Viral, Electrophoresis, Agar Gel, Epstein-Barr Virus Infections, Female, Herpesvirus 4, Human, Humans, Lichen Planus, Oral, Logistic Models, Male, Middle Aged, Mouth Mucosa, Mouth Neoplasms, Odds Ratio, Polymerase Chain Reaction, Risk Factors, Smoking, Statistics as Topic, Tobacco, Smokeless, Comparative Study, Journal Article, Multicenter Study
in
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
volume
93
issue
5
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:0036559633
ISSN
1079-2104
DOI
10.1067/moe.2002.124462
language
English
LU publication?
no
id
73b99450-0454-4d75-822c-1bf1b50bb39e
date added to LUP
2017-05-11 23:38:09
date last changed
2017-11-05 05:17:19
@article{73b99450-0454-4d75-822c-1bf1b50bb39e,
  abstract     = {<p>OBJECTIVE: The Epstein-Barr virus (EBV) is associated with both malignant and benign diseases in the head and neck region. In several studies it has also been associated with oral squamous cell carcinoma (OSCC). Oral lichen planus (OLP) is a disease with unknown origin, and viral antigens have been proposed as etiologic agents. Smoking and alcohol habits are known risk factors for oral cancer development. In this study, the prevalence of EBV in OSCC and OLP was investigated, along with the effect of smoking, alcohol use, and age on EBV prevalence.</p><p>STUDY DESIGN: We examined 29 patients with OSCC, 23 with OLP, and 67 with clinically healthy oral mucosa. For EBV DNA analysis, a nested polymerase chain reaction method was used.</p><p>RESULTS: The overall EBV prevalence in patients with oral disease was 32.1%. Of the OSCC patients, 37.9% were EBV positive; and of the OLP patients, 26.1% were EBV positive. Both percentages were statistically significant compared with that of control patients (7.3%). The difference in EBV prevalence between the smoking control group and the nonsmoking control group was insignificant. Increased age did not enhance EBV prevalence.</p><p>CONCLUSIONS: This investigation shows that EBV is present in oral diseases such as OSCC and OLP. Smoking, alcohol use, or age does not seem to be a risk factor for EBV infection. The etiologic role of EBV in OSCC and OLP needs to be examined in a prospective follow-up study.</p>},
  author       = {Sand, Lars Peter and Jalouli, Jamshid and Larsson, Per-Anders and Hirsch, Jan-Michael},
  issn         = {1079-2104},
  keyword      = {Adult,Age Factors,Aged,Aged, 80 and over,Alcohol Drinking,Carcinoma, Squamous Cell,Case-Control Studies,Cocarcinogenesis,DNA, Viral,Electrophoresis, Agar Gel,Epstein-Barr Virus Infections,Female,Herpesvirus 4, Human,Humans,Lichen Planus, Oral,Logistic Models,Male,Middle Aged,Mouth Mucosa,Mouth Neoplasms,Odds Ratio,Polymerase Chain Reaction,Risk Factors,Smoking,Statistics as Topic,Tobacco, Smokeless,Comparative Study,Journal Article,Multicenter Study},
  language     = {eng},
  number       = {5},
  pages        = {92--586},
  publisher    = {Elsevier},
  series       = {Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics},
  title        = {Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa},
  url          = {http://dx.doi.org/10.1067/moe.2002.124462},
  volume       = {93},
  year         = {2002},
}