Kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy based on multiple small VOIs
(2024) In Physica Medica 120.- Abstract
Purpose: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy. Method: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed to determine the average activity concentration (AC) in each kidney. The study consisted of three steps: (i) determination of the number of iterations for AC convergence based on simulated images; (ii) determination of recovery-coefficients (RCs) for 2 mL VOIs using a separate set of simulated images; (iii) assessment of operator... (More)
Purpose: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy. Method: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed to determine the average activity concentration (AC) in each kidney. The study consisted of three steps: (i) determination of the number of iterations for AC convergence based on simulated images; (ii) determination of recovery-coefficients (RCs) for 2 mL VOIs using a separate set of simulated images; (iii) assessment of operator variability in AC estimates for simulated and patient images. Five operators placed the VOIs, using for guidance: a) SPECT/CT with RR, b) SPECT/CT without RR, and c) CT only. For simulated images, time-integrated ACs (TIACs) were evaluated. For patient images, estimated ACs were compared with results of a previous method based on whole-kidney VOIs. Results: Eight iterations and ten subsets were sufficient for both programs and reconstruction settings. Mean RCs (mean ± SD) with RR were 1.03 ± 0.02 (LundaDose) and 1.10 ± 0.03 (Hermia), and without RR 0.91 ± 0.03 (LundaDose) and 0.94 ± 0.03 (Hermia). Most stable and accurate estimates of the AC were obtained using five 2-mL VOIs guided by SPECT/CT with RR, applying them to images without RR, and including an explicit RC for recovery correction. Conclusion: The small VOI method based on five 2-mL VOIs was found efficient and sufficiently accurate for kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy.
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- author
- Curkic Kapidzic, Selma LU ; Gustafsson, Johan LU ; Larsson, Erik ; Jessen, Lovisa LU and Sjögreen Gleisner, Katarina LU
- organization
- publishing date
- 2024-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lu-PRRT, Dosimetry, Kidneys, Quantitative SPECT
- in
- Physica Medica
- volume
- 120
- article number
- 103335
- publisher
- ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI
- external identifiers
-
- pmid:38555793
- scopus:85189138702
- ISSN
- 1120-1797
- DOI
- 10.1016/j.ejmp.2024.103335
- language
- English
- LU publication?
- yes
- id
- 73cff6cd-0b97-45ac-85b3-4d7b9ee14661
- date added to LUP
- 2024-04-17 15:27:51
- date last changed
- 2024-04-18 03:00:04
@article{73cff6cd-0b97-45ac-85b3-4d7b9ee14661,
abstract = {{<p>Purpose: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [<sup>177</sup>Lu]Lu-DOTA-TATE therapy. Method: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed to determine the average activity concentration (AC) in each kidney. The study consisted of three steps: (i) determination of the number of iterations for AC convergence based on simulated images; (ii) determination of recovery-coefficients (RCs) for 2 mL VOIs using a separate set of simulated images; (iii) assessment of operator variability in AC estimates for simulated and patient images. Five operators placed the VOIs, using for guidance: a) SPECT/CT with RR, b) SPECT/CT without RR, and c) CT only. For simulated images, time-integrated ACs (TIACs) were evaluated. For patient images, estimated ACs were compared with results of a previous method based on whole-kidney VOIs. Results: Eight iterations and ten subsets were sufficient for both programs and reconstruction settings. Mean RCs (mean ± SD) with RR were 1.03 ± 0.02 (LundaDose) and 1.10 ± 0.03 (Hermia), and without RR 0.91 ± 0.03 (LundaDose) and 0.94 ± 0.03 (Hermia). Most stable and accurate estimates of the AC were obtained using five 2-mL VOIs guided by SPECT/CT with RR, applying them to images without RR, and including an explicit RC for recovery correction. Conclusion: The small VOI method based on five 2-mL VOIs was found efficient and sufficiently accurate for kidney dosimetry in [<sup>177</sup>Lu]Lu-DOTA-TATE therapy.</p>}},
author = {{Curkic Kapidzic, Selma and Gustafsson, Johan and Larsson, Erik and Jessen, Lovisa and Sjögreen Gleisner, Katarina}},
issn = {{1120-1797}},
keywords = {{Lu-PRRT; Dosimetry; Kidneys; Quantitative SPECT}},
language = {{eng}},
publisher = {{ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI}},
series = {{Physica Medica}},
title = {{Kidney dosimetry in [<sup>177</sup>Lu]Lu-DOTA-TATE therapy based on multiple small VOIs}},
url = {{http://dx.doi.org/10.1016/j.ejmp.2024.103335}},
doi = {{10.1016/j.ejmp.2024.103335}},
volume = {{120}},
year = {{2024}},
}