Making a Hematopoietic Stem Cell
Daniel, Michael G. ; Pereira, Carlos Filipe LU
; Lemischka, Ihor R.
and Moore, Kateri A.
(2016)
In Trends in Cell Biology
26(3).
p.202-214
- Abstract
Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo generation from pluripotent stem cells (PSCs), comprising both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). iPSCs alleviated ESC ethical issues but attempts to generate functional mature hematopoietic stem and progenitor cells (HSPCs) have been largely unsuccessful. New efforts focus on directly reprogramming somatic cells into definitive HSCs and HSPCs. To meet clinical needs and to advance drug discovery and stem cell therapy, alternative approaches are necessary. In this review, we synthesize the strategies used and the key findings... (More)
Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo generation from pluripotent stem cells (PSCs), comprising both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). iPSCs alleviated ESC ethical issues but attempts to generate functional mature hematopoietic stem and progenitor cells (HSPCs) have been largely unsuccessful. New efforts focus on directly reprogramming somatic cells into definitive HSCs and HSPCs. To meet clinical needs and to advance drug discovery and stem cell therapy, alternative approaches are necessary. In this review, we synthesize the strategies used and the key findings made in recent years by those trying to make an HSC.
(Less)
- author
- Daniel, Michael G.
; Pereira, Carlos Filipe
LU
; Lemischka, Ihor R.
and Moore, Kateri A.
- publishing date
- 2016-03-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Hematopoiesis, Hematopoietic stem cell, Reprogramming, Transcription factors
- in
- Trends in Cell Biology
- volume
- 26
- issue
- 3
- pages
- 13 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:26526106
- scopus:84958672483
- ISSN
- 0962-8924
- DOI
- 10.1016/j.tcb.2015.10.002
- language
- English
- LU publication?
- no
- id
- 73dc84cf-1768-46ef-94de-a537e8f87e5d
- date added to LUP
- 2017-10-02 17:24:54
- date last changed
- 2024-05-26 23:34:48
@article{73dc84cf-1768-46ef-94de-a537e8f87e5d,
abstract = {{<p>Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo generation from pluripotent stem cells (PSCs), comprising both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). iPSCs alleviated ESC ethical issues but attempts to generate functional mature hematopoietic stem and progenitor cells (HSPCs) have been largely unsuccessful. New efforts focus on directly reprogramming somatic cells into definitive HSCs and HSPCs. To meet clinical needs and to advance drug discovery and stem cell therapy, alternative approaches are necessary. In this review, we synthesize the strategies used and the key findings made in recent years by those trying to make an HSC.</p>}},
author = {{Daniel, Michael G. and Pereira, Carlos Filipe and Lemischka, Ihor R. and Moore, Kateri A.}},
issn = {{0962-8924}},
keywords = {{Hematopoiesis; Hematopoietic stem cell; Reprogramming; Transcription factors}},
language = {{eng}},
month = {{03}},
number = {{3}},
pages = {{202--214}},
publisher = {{Elsevier}},
series = {{Trends in Cell Biology}},
title = {{Making a Hematopoietic Stem Cell}},
url = {{http://dx.doi.org/10.1016/j.tcb.2015.10.002}},
doi = {{10.1016/j.tcb.2015.10.002}},
volume = {{26}},
year = {{2016}},
}