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Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment—Case of COVID-19

Vihinen, Mauno LU orcid (2020) In Frontiers in Medicine 7.
Abstract

A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures—extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as... (More)

A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures—extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COVID-19, diagnosis, pathogenicity model, poikilosis, progression prediction, SARS-CoV-2
in
Frontiers in Medicine
volume
7
article number
294
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85087299904
  • pmid:32613004
ISSN
2296-858X
DOI
10.3389/fmed.2020.00294
language
English
LU publication?
yes
id
73f444b7-e6e1-4f88-b7f0-ce93d5b7d872
date added to LUP
2020-07-16 11:42:49
date last changed
2024-06-12 17:44:28
@article{73f444b7-e6e1-4f88-b7f0-ce93d5b7d872,
  abstract     = {{<p>A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures—extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.</p>}},
  author       = {{Vihinen, Mauno}},
  issn         = {{2296-858X}},
  keywords     = {{COVID-19; diagnosis; pathogenicity model; poikilosis; progression prediction; SARS-CoV-2}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Medicine}},
  title        = {{Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment—Case of COVID-19}},
  url          = {{http://dx.doi.org/10.3389/fmed.2020.00294}},
  doi          = {{10.3389/fmed.2020.00294}},
  volume       = {{7}},
  year         = {{2020}},
}