Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity
(2004) In FEBS Letters 560(1-3). p.41339-41339- Abstract
- Abstract
Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/740255
- author
- Piskur, Jure LU ; Sandrini, Michael LU ; Knecht, W. LU and Munch-Petersen, Birgitte LU
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- nucleic acid precursors, evolution, enzyme, kinases
- in
- FEBS Letters
- volume
- 560
- issue
- 1-3
- pages
- 41339 - 41339
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000189328900002
- scopus:1342286828
- ISSN
- 1873-3468
- DOI
- 10.1016/S0014-5793(04)00081-X
- language
- English
- LU publication?
- no
- id
- ceb21c1a-3f87-4e30-97c3-be601b056dae (old id 740255)
- date added to LUP
- 2016-04-01 16:26:51
- date last changed
- 2022-04-07 08:19:15
@article{ceb21c1a-3f87-4e30-97c3-be601b056dae, abstract = {{Abstract<br/><br> Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.}}, author = {{Piskur, Jure and Sandrini, Michael and Knecht, W. and Munch-Petersen, Birgitte}}, issn = {{1873-3468}}, keywords = {{nucleic acid precursors; evolution; enzyme; kinases}}, language = {{eng}}, number = {{1-3}}, pages = {{41339--41339}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity}}, url = {{http://dx.doi.org/10.1016/S0014-5793(04)00081-X}}, doi = {{10.1016/S0014-5793(04)00081-X}}, volume = {{560}}, year = {{2004}}, }