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Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity

Piskur, Jure LU ; Sandrini, Michael LU ; Knecht, W. and Munch-Petersen, Birgitte LU (2004) In FEBS Letters 560(1-3). p.41339-41339
Abstract
Abstract

Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nucleic acid precursors, evolution, enzyme, kinases
in
FEBS Letters
volume
560
issue
1-3
pages
41339 - 41339
publisher
Wiley-Blackwell
external identifiers
  • wos:000189328900002
  • scopus:1342286828
ISSN
1873-3468
DOI
10.1016/S0014-5793(04)00081-X
language
English
LU publication?
yes
id
ceb21c1a-3f87-4e30-97c3-be601b056dae (old id 740255)
date added to LUP
2008-01-09 14:49:54
date last changed
2017-01-08 05:06:35
@article{ceb21c1a-3f87-4e30-97c3-be601b056dae,
  abstract     = {Abstract<br/><br>
Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.},
  author       = {Piskur, Jure and Sandrini, Michael and Knecht, W. and Munch-Petersen, Birgitte},
  issn         = {1873-3468},
  keyword      = {nucleic acid precursors,evolution,enzyme,kinases},
  language     = {eng},
  number       = {1-3},
  pages        = {41339--41339},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity},
  url          = {http://dx.doi.org/10.1016/S0014-5793(04)00081-X},
  volume       = {560},
  year         = {2004},
}