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Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer

Kumler, Iben; Parner, Vibeke Kirk; Tuxen, Malgorzata K.; Skjoldbye, Bjorn; Bergenfeldt, Magnus LU ; Nelausen, Knud Mejer and Nielsen, Dorte Lisbet (2015) In Radiologia Medica 120(6). p.536-541
Abstract
Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in... (More)
Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Liver metastases, Metastatic breast cancer, Radiofrequency ablation
in
Radiologia Medica
volume
120
issue
6
pages
536 - 541
publisher
Edizioni Minerva Medica
external identifiers
  • wos:000354636100006
  • scopus:84938534581
ISSN
0033-8362
DOI
10.1007/s11547-014-0489-6
language
English
LU publication?
yes
id
0708ca05-d690-482a-8e9a-885007d05a67 (old id 7411617)
date added to LUP
2015-07-03 07:03:43
date last changed
2017-10-01 03:30:05
@article{0708ca05-d690-482a-8e9a-885007d05a67,
  abstract     = {Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups.},
  author       = {Kumler, Iben and Parner, Vibeke Kirk and Tuxen, Malgorzata K. and Skjoldbye, Bjorn and Bergenfeldt, Magnus and Nelausen, Knud Mejer and Nielsen, Dorte Lisbet},
  issn         = {0033-8362},
  keyword      = {Liver metastases,Metastatic breast cancer,Radiofrequency ablation},
  language     = {eng},
  number       = {6},
  pages        = {536--541},
  publisher    = {Edizioni Minerva Medica},
  series       = {Radiologia Medica},
  title        = {Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer},
  url          = {http://dx.doi.org/10.1007/s11547-014-0489-6},
  volume       = {120},
  year         = {2015},
}