Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer
(2015) In Radiologia Medica 120(6). p.536-541- Abstract
- Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in... (More)
- Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7411617
- author
- Kumler, Iben ; Parner, Vibeke Kirk ; Tuxen, Malgorzata K. ; Skjoldbye, Bjorn ; Bergenfeldt, Magnus LU ; Nelausen, Knud Mejer and Nielsen, Dorte Lisbet
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Liver metastases, Metastatic breast cancer, Radiofrequency ablation
- in
- Radiologia Medica
- volume
- 120
- issue
- 6
- pages
- 536 - 541
- publisher
- Edizioni Minerva Medica
- external identifiers
-
- wos:000354636100006
- scopus:84938534581
- pmid:25572543
- ISSN
- 0033-8362
- DOI
- 10.1007/s11547-014-0489-6
- language
- English
- LU publication?
- yes
- id
- 0708ca05-d690-482a-8e9a-885007d05a67 (old id 7411617)
- date added to LUP
- 2016-04-01 11:06:15
- date last changed
- 2022-03-12 19:53:20
@article{0708ca05-d690-482a-8e9a-885007d05a67, abstract = {{Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor. Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010. Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %. In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups.}}, author = {{Kumler, Iben and Parner, Vibeke Kirk and Tuxen, Malgorzata K. and Skjoldbye, Bjorn and Bergenfeldt, Magnus and Nelausen, Knud Mejer and Nielsen, Dorte Lisbet}}, issn = {{0033-8362}}, keywords = {{Liver metastases; Metastatic breast cancer; Radiofrequency ablation}}, language = {{eng}}, number = {{6}}, pages = {{536--541}}, publisher = {{Edizioni Minerva Medica}}, series = {{Radiologia Medica}}, title = {{Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer}}, url = {{http://dx.doi.org/10.1007/s11547-014-0489-6}}, doi = {{10.1007/s11547-014-0489-6}}, volume = {{120}}, year = {{2015}}, }