Hypertension in primary hyperparathyroidism in relation to histopathology
(1991) In European Journal of Surgery 157(8). p.457-459- Abstract
- Hypertension in primary hyperparathyroidism (HPT) was previously attributed to hypercalcemia per se or to impaired kidney function. Of 441 consecutive patients operated on for HPT over 24 years, 57% were hypertensive. Preoperative blood pressure remained fairly constant during the study period, despite otherwise markedly changing clinical picture with, latterly, more asymptomatic patients. The preoperative systolic blood pressure (SBP) was significantly correlated to both serum calcium (p less than 0.001) and serum creatinine (p less than 0.05), but not when the influence of age was taken into account in a multiple regression analysis. Other pathogenetic factors in hypertension were therefore probable. When the statistical analysis was... (More)
- Hypertension in primary hyperparathyroidism (HPT) was previously attributed to hypercalcemia per se or to impaired kidney function. Of 441 consecutive patients operated on for HPT over 24 years, 57% were hypertensive. Preoperative blood pressure remained fairly constant during the study period, despite otherwise markedly changing clinical picture with, latterly, more asymptomatic patients. The preoperative systolic blood pressure (SBP) was significantly correlated to both serum calcium (p less than 0.001) and serum creatinine (p less than 0.05), but not when the influence of age was taken into account in a multiple regression analysis. Other pathogenetic factors in hypertension were therefore probable. When the statistical analysis was adjusted for differences in age and serum calcium, blood pressure was lower in the HPT patients with parathyroid hyperplasia than in those with adenoma (153 +/- 31/90 +/- 14 vs. 163 +/- 29/91 +/- 14 mmHg, p less than 0.01 for SBP). The concept that parathyroid hyperplasia represents a mild (early) form of HPT that may precede adenoma formation is corroborated by our observations, which also indicate that there is no simple cause-and-effect relationship accounting for hypertension in primary HPT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106048
- author
- Lind, L ; Hvarfner, Andreas LU ; Palmer, M ; Grimelius, L ; Akerstrom, G and Ljunghall, S
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Surgery
- volume
- 157
- issue
- 8
- pages
- 457 - 459
- publisher
- Oxford University Press
- external identifiers
-
- pmid:1681931
- scopus:0025939463
- ISSN
- 1102-4151
- language
- English
- LU publication?
- yes
- id
- 74117f73-5aaf-4b71-82bc-37cfa03b5568 (old id 1106048)
- date added to LUP
- 2016-04-01 16:35:09
- date last changed
- 2021-01-03 09:54:49
@article{74117f73-5aaf-4b71-82bc-37cfa03b5568,
abstract = {{Hypertension in primary hyperparathyroidism (HPT) was previously attributed to hypercalcemia per se or to impaired kidney function. Of 441 consecutive patients operated on for HPT over 24 years, 57% were hypertensive. Preoperative blood pressure remained fairly constant during the study period, despite otherwise markedly changing clinical picture with, latterly, more asymptomatic patients. The preoperative systolic blood pressure (SBP) was significantly correlated to both serum calcium (p less than 0.001) and serum creatinine (p less than 0.05), but not when the influence of age was taken into account in a multiple regression analysis. Other pathogenetic factors in hypertension were therefore probable. When the statistical analysis was adjusted for differences in age and serum calcium, blood pressure was lower in the HPT patients with parathyroid hyperplasia than in those with adenoma (153 +/- 31/90 +/- 14 vs. 163 +/- 29/91 +/- 14 mmHg, p less than 0.01 for SBP). The concept that parathyroid hyperplasia represents a mild (early) form of HPT that may precede adenoma formation is corroborated by our observations, which also indicate that there is no simple cause-and-effect relationship accounting for hypertension in primary HPT.}},
author = {{Lind, L and Hvarfner, Andreas and Palmer, M and Grimelius, L and Akerstrom, G and Ljunghall, S}},
issn = {{1102-4151}},
language = {{eng}},
number = {{8}},
pages = {{457--459}},
publisher = {{Oxford University Press}},
series = {{European Journal of Surgery}},
title = {{Hypertension in primary hyperparathyroidism in relation to histopathology}},
volume = {{157}},
year = {{1991}},
}