Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
(2004) In Infection and Immunity 72(6). p.3515-3523- Abstract
- Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent... (More)
- Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141861
- author
- Viau, Muriel ; Longo, Nancy S ; Lipsky, Peter E ; Björck, Lars LU and Zouali, Moncef
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infection and Immunity
- volume
- 72
- issue
- 6
- pages
- 3515 - 3523
- publisher
- American Society for Microbiology
- external identifiers
-
- wos:000221662400051
- pmid:15155659
- scopus:2542562891
- pmid:15155659
- ISSN
- 1098-5522
- DOI
- 10.1128/IAI.72.6.3515-3523.2004
- language
- English
- LU publication?
- yes
- id
- 741350e1-6841-4e3b-b148-4f26f1daddc1 (old id 141861)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15155659&query_hl=61
- date added to LUP
- 2016-04-01 11:43:56
- date last changed
- 2022-04-28 19:11:40
@article{741350e1-6841-4e3b-b148-4f26f1daddc1,
abstract = {{Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense.}},
author = {{Viau, Muriel and Longo, Nancy S and Lipsky, Peter E and Björck, Lars and Zouali, Moncef}},
issn = {{1098-5522}},
language = {{eng}},
number = {{6}},
pages = {{3515--3523}},
publisher = {{American Society for Microbiology}},
series = {{Infection and Immunity}},
title = {{Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L}},
url = {{https://lup.lub.lu.se/search/files/2616086/624790.pdf}},
doi = {{10.1128/IAI.72.6.3515-3523.2004}},
volume = {{72}},
year = {{2004}},
}