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Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial

Akerstrom, Ulf; Reitamo, Sakari; Langeland, Tor; Berg, Mats; Rustad, Lisbeth; Korhonen, Laura; Loden, Marie; Wiren, Karin; Grande, Mats and Skare, Petra, et al. (2015) In Acta Dermato-Venereologica 95(5). p.587-592
Abstract
Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time... (More)
Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD. (Less)
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Contribution to journal
publication status
published
subject
keywords
atopic dermatitis, atopic eczema, emollients, moisturizer, prevention, urea
in
Acta Dermato-Venereologica
volume
95
issue
5
pages
587 - 592
publisher
Medical Journals Limited
external identifiers
  • wos:000355057100014
  • scopus:84928152035
ISSN
1651-2057
DOI
10.2340/00015555-2051
language
English
LU publication?
yes
id
aaafb053-c716-4180-9b39-b50f01361640 (old id 7422486)
date added to LUP
2015-07-03 07:04:00
date last changed
2017-09-17 06:58:26
@article{aaafb053-c716-4180-9b39-b50f01361640,
  abstract     = {Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.},
  author       = {Akerstrom, Ulf and Reitamo, Sakari and Langeland, Tor and Berg, Mats and Rustad, Lisbeth and Korhonen, Laura and Loden, Marie and Wiren, Karin and Grande, Mats and Skare, Petra and Svensson, Åke},
  issn         = {1651-2057},
  keyword      = {atopic dermatitis,atopic eczema,emollients,moisturizer,prevention,urea},
  language     = {eng},
  number       = {5},
  pages        = {587--592},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial},
  url          = {http://dx.doi.org/10.2340/00015555-2051},
  volume       = {95},
  year         = {2015},
}