Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial
(2015) In Acta Dermato-Venereologica 95(5). p.587-592- Abstract
- Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time... (More)
- Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7422486
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atopic dermatitis, atopic eczema, emollients, moisturizer, prevention, urea
- in
- Acta Dermato-Venereologica
- volume
- 95
- issue
- 5
- pages
- 587 - 592
- publisher
- Medical Journals Limited
- external identifiers
-
- wos:000355057100014
- scopus:84928152035
- pmid:25594845
- ISSN
- 1651-2057
- DOI
- 10.2340/00015555-2051
- language
- English
- LU publication?
- yes
- id
- aaafb053-c716-4180-9b39-b50f01361640 (old id 7422486)
- date added to LUP
- 2016-04-01 15:04:36
- date last changed
- 2022-02-19 22:20:53
@article{aaafb053-c716-4180-9b39-b50f01361640, abstract = {{Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.}}, author = {{Akerstrom, Ulf and Reitamo, Sakari and Langeland, Tor and Berg, Mats and Rustad, Lisbeth and Korhonen, Laura and Loden, Marie and Wiren, Karin and Grande, Mats and Skare, Petra and Svensson, Åke}}, issn = {{1651-2057}}, keywords = {{atopic dermatitis; atopic eczema; emollients; moisturizer; prevention; urea}}, language = {{eng}}, number = {{5}}, pages = {{587--592}}, publisher = {{Medical Journals Limited}}, series = {{Acta Dermato-Venereologica}}, title = {{Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial}}, url = {{https://lup.lub.lu.se/search/files/4328162/8523714}}, doi = {{10.2340/00015555-2051}}, volume = {{95}}, year = {{2015}}, }