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Impact of fasting glucose on electrocardiographic left ventricular hypertrophy in an elderly general population

Diederichsen, Soren Z.; Pareek, Manan; Nielsen, Mette L.; D'Souza, Maria; Leosdottir, Margret; Nilsson, Peter LU and Olsen, Michael H. (2015) In Blood Pressure 24(3). p.164-173
Abstract
Objective. To evaluate relationships between fasting plasma glucose (FPG), other cardiovascular risk markers and left ventricular hypertrophy (LVH) as detected by electrocardiography. Methods. Subjects were selected randomly from groups defi ned by FPG. Traditional risk markers were assessed. LVH was defi ned by either Cornell voltage -duration product (CP) or Sokolow -Lyon voltage combination (SL), and univariate and multivariable regressions were performed in search of explanatory factors for the presence of LVH and the values of CP and SL. Results. Of the 1759 subjects included, 1007 had a history of cardiovascular disease and/or medical treatment, while 752 subjects appeared to be healthy. We found an independent association between... (More)
Objective. To evaluate relationships between fasting plasma glucose (FPG), other cardiovascular risk markers and left ventricular hypertrophy (LVH) as detected by electrocardiography. Methods. Subjects were selected randomly from groups defi ned by FPG. Traditional risk markers were assessed. LVH was defi ned by either Cornell voltage -duration product (CP) or Sokolow -Lyon voltage combination (SL), and univariate and multivariable regressions were performed in search of explanatory factors for the presence of LVH and the values of CP and SL. Results. Of the 1759 subjects included, 1007 had a history of cardiovascular disease and/or medical treatment, while 752 subjects appeared to be healthy. We found an independent association between FPG and LVH (odds ratio 1.152, p = 0.042] as well as continuous CP (beta = 0.126, p = 0.007) in healthy men. As expected, we found an association between systolic blood pressure and LVH (odds ratio 1.020, p < 0.001) among healthy subjects, but only in subjects with FPG < 6 mmol/l (p = 0.04 for interaction). Conclusions. We found an independent association between FPG and LVH in healthy men, and no potentiating effect by FPG on the impact of hypertension. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, diabetes mellitus, electrocardiography, glucose, hypertension, left ventricular hypertrophy
in
Blood Pressure
volume
24
issue
3
pages
164 - 173
publisher
Taylor & Francis
external identifiers
  • wos:000354191800005
  • scopus:84928990166
ISSN
0803-7051
DOI
10.3109/08037051.2015.1030892
language
English
LU publication?
yes
id
b898d88c-5a97-47c2-afe5-96ebffc7bf11 (old id 7424980)
date added to LUP
2015-07-03 07:05:14
date last changed
2017-01-15 03:04:16
@article{b898d88c-5a97-47c2-afe5-96ebffc7bf11,
  abstract     = {Objective. To evaluate relationships between fasting plasma glucose (FPG), other cardiovascular risk markers and left ventricular hypertrophy (LVH) as detected by electrocardiography. Methods. Subjects were selected randomly from groups defi ned by FPG. Traditional risk markers were assessed. LVH was defi ned by either Cornell voltage -duration product (CP) or Sokolow -Lyon voltage combination (SL), and univariate and multivariable regressions were performed in search of explanatory factors for the presence of LVH and the values of CP and SL. Results. Of the 1759 subjects included, 1007 had a history of cardiovascular disease and/or medical treatment, while 752 subjects appeared to be healthy. We found an independent association between FPG and LVH (odds ratio 1.152, p = 0.042] as well as continuous CP (beta = 0.126, p = 0.007) in healthy men. As expected, we found an association between systolic blood pressure and LVH (odds ratio 1.020, p &lt; 0.001) among healthy subjects, but only in subjects with FPG &lt; 6 mmol/l (p = 0.04 for interaction). Conclusions. We found an independent association between FPG and LVH in healthy men, and no potentiating effect by FPG on the impact of hypertension.},
  author       = {Diederichsen, Soren Z. and Pareek, Manan and Nielsen, Mette L. and D'Souza, Maria and Leosdottir, Margret and Nilsson, Peter and Olsen, Michael H.},
  issn         = {0803-7051},
  keyword      = {Aged,diabetes mellitus,electrocardiography,glucose,hypertension,left ventricular hypertrophy},
  language     = {eng},
  number       = {3},
  pages        = {164--173},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Impact of fasting glucose on electrocardiographic left ventricular hypertrophy in an elderly general population},
  url          = {http://dx.doi.org/10.3109/08037051.2015.1030892},
  volume       = {24},
  year         = {2015},
}