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Development of Stable Long-term Electrode Tissue Interfaces for Recording and Stimulation

Schouenborg, Jens LU (2016) In Neurobionics: The Biomedical Engineering of Neural Prostheses p.38-54
Abstract

Summary: Brain Computer interfaces (BCIs) are stable inside the brain over long periods of time and that have minimal effects on the physiological conditions of the neural tissue. This chapter reviews the state-of-the-art of neural interfaces and the concepts behind recent research and development of biocompatible BCIs. It focuses on various tissue responses in the brain to an implanted foreign body. A number of implantable micro-electrode arrays have been developed for use as neural interfaces for BCIs. The chapter then focuses on how to minimize the foreign body reactions and loss of neurons around the implant that has resulted in identification of several key features that electrodes need to fulfill and the development of novel... (More)

Summary: Brain Computer interfaces (BCIs) are stable inside the brain over long periods of time and that have minimal effects on the physiological conditions of the neural tissue. This chapter reviews the state-of-the-art of neural interfaces and the concepts behind recent research and development of biocompatible BCIs. It focuses on various tissue responses in the brain to an implanted foreign body. A number of implantable micro-electrode arrays have been developed for use as neural interfaces for BCIs. The chapter then focuses on how to minimize the foreign body reactions and loss of neurons around the implant that has resulted in identification of several key features that electrodes need to fulfill and the development of novel ultra-thin/elastic and flexible constructs that fulfill these requirements. By using hard but dissolvable matrix materials, arrays of ultra-flexible electrodes can be implanted. Importantly, gelatin-based embedding materials also appear to protect the neurons close to the BCI.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Biocompatibility, Brain computer interfaces, Brain implants, Gelatin, Long-term electrode tissue interfaces, Neural interfaces, Ultra-flexible electrodes
in
Neurobionics: The Biomedical Engineering of Neural Prostheses
pages
17 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85026693647
ISBN
9781118816028
9781118814871
DOI
10.1002/9781118816028.ch2
language
English
LU publication?
yes
id
7432b450-428c-4021-8f1c-42d0f66eb060
date added to LUP
2017-08-31 13:07:12
date last changed
2017-08-31 13:07:12
@inbook{7432b450-428c-4021-8f1c-42d0f66eb060,
  abstract     = {<p>Summary: Brain Computer interfaces (BCIs) are stable inside the brain over long periods of time and that have minimal effects on the physiological conditions of the neural tissue. This chapter reviews the state-of-the-art of neural interfaces and the concepts behind recent research and development of biocompatible BCIs. It focuses on various tissue responses in the brain to an implanted foreign body. A number of implantable micro-electrode arrays have been developed for use as neural interfaces for BCIs. The chapter then focuses on how to minimize the foreign body reactions and loss of neurons around the implant that has resulted in identification of several key features that electrodes need to fulfill and the development of novel ultra-thin/elastic and flexible constructs that fulfill these requirements. By using hard but dissolvable matrix materials, arrays of ultra-flexible electrodes can be implanted. Importantly, gelatin-based embedding materials also appear to protect the neurons close to the BCI.</p>},
  author       = {Schouenborg, Jens},
  isbn         = {9781118816028},
  keyword      = {Biocompatibility,Brain computer interfaces,Brain implants,Gelatin,Long-term electrode tissue interfaces,Neural interfaces,Ultra-flexible electrodes},
  language     = {eng},
  month        = {09},
  pages        = {38--54},
  publisher    = {Wiley-Blackwell},
  series       = {Neurobionics: The Biomedical Engineering of Neural Prostheses},
  title        = {Development of Stable Long-term Electrode Tissue Interfaces for Recording and Stimulation},
  url          = {http://dx.doi.org/10.1002/9781118816028.ch2},
  year         = {2016},
}