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Anabolic and antiresorptive actions of locally delivered bisphosphonates for bone repair

Qayoom, I.; Raina, D. B. LU ; Širka, A.; Tarasevičius, LU ; Tägil, M. LU ; Kumar, A. LU and Lidgren, L. LU (2018) In Bone and Joint Research 7(10). p.548-560
Abstract

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has become obvious that the carrier is of importance to modulate the concentration and elution profile of the zoledronic acid locally. Incorporating one fifth of the recommended systemic dose of zoledronate with different apatite matrices and types of bone defects has been shown to enhance bone regeneration significantly in vivo. We expect the local... (More)

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has become obvious that the carrier is of importance to modulate the concentration and elution profile of the zoledronic acid locally. Incorporating one fifth of the recommended systemic dose of zoledronate with different apatite matrices and types of bone defects has been shown to enhance bone regeneration significantly in vivo. We expect the local delivery of zoledronate to overcome the limitations and side effects associated with systemic usage; however, we need to know more about the bioavailability and the biological effects. The local use of BMp-2 and zoledronate as a combination has a proven additional effect on bone regeneration. This review focuses primarily on the local use of zoledronate alone, or in combination with bone anabolic factors, in various preclinical models mimicking different orthopaedic conditions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bisphosphonates, Bone repair, Carrier, Ceramic, Local delivery, Zoledronic acid
in
Bone and Joint Research
volume
7
issue
10
pages
13 pages
publisher
British Editorial Soc Bone Joint Surgery
external identifiers
  • scopus:85056103399
ISSN
2046-3758
DOI
10.1302/2046-3758.710.BJR-2018-0015.R2
language
English
LU publication?
yes
id
7451a83c-f967-4e79-9ce7-6a248ef3b657
date added to LUP
2018-11-22 14:05:40
date last changed
2019-02-20 11:37:17
@article{7451a83c-f967-4e79-9ce7-6a248ef3b657,
  abstract     = {<p>During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has become obvious that the carrier is of importance to modulate the concentration and elution profile of the zoledronic acid locally. Incorporating one fifth of the recommended systemic dose of zoledronate with different apatite matrices and types of bone defects has been shown to enhance bone regeneration significantly in vivo. We expect the local delivery of zoledronate to overcome the limitations and side effects associated with systemic usage; however, we need to know more about the bioavailability and the biological effects. The local use of BMp-2 and zoledronate as a combination has a proven additional effect on bone regeneration. This review focuses primarily on the local use of zoledronate alone, or in combination with bone anabolic factors, in various preclinical models mimicking different orthopaedic conditions.</p>},
  author       = {Qayoom, I. and Raina, D. B. and Širka, A. and Tarasevičius,  and Tägil, M. and Kumar, A. and Lidgren, L.},
  issn         = {2046-3758},
  keyword      = {Bisphosphonates,Bone repair,Carrier,Ceramic,Local delivery,Zoledronic acid},
  language     = {eng},
  month        = {10},
  number       = {10},
  pages        = {548--560},
  publisher    = {British Editorial Soc Bone Joint Surgery},
  series       = {Bone and Joint Research},
  title        = {Anabolic and antiresorptive actions of locally delivered bisphosphonates for bone repair},
  url          = {http://dx.doi.org/10.1302/2046-3758.710.BJR-2018-0015.R2},
  volume       = {7},
  year         = {2018},
}