Understanding the evolution of immune genes in jawed vertebrates
(2023) In Journal of evolutionary biology 36(6). p.847-873- Abstract
Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into—and generate evolutionary hypotheses on—the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the... (More)
Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into—and generate evolutionary hypotheses on—the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the immunome concept, a framework for characterizing genes involved in immune defence from a comparative perspective, then we outline how immune genes of interest can be identified. Second, we focus on how different selection modes are observed acting across groups of immune genes and propose hypotheses to explain these differences. We then provide an overview of the approaches used so far to study the evolutionary heterogeneity of immune genes on macro and microevolutionary scales. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes. This review results from the collective discussion on the current key challenges in evolutionary immunology conducted at the ESEB 2021 Online Satellite Symposium: Molecular evolution of the vertebrate immune system, from the lab to natural populations.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adaptation, adaptive immunity, evolutionary immunology, genomics, host-parasite interactions, immunogenetics, innate immunity, MHC, molecular evolution, vertebrates
- in
- Journal of evolutionary biology
- volume
- 36
- issue
- 6
- pages
- 27 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:37255207
- scopus:85161121532
- ISSN
- 1010-061X
- DOI
- 10.1111/jeb.14181
- language
- English
- LU publication?
- yes
- id
- 745e029d-e306-4d8b-b82b-9ee4ff8411de
- date added to LUP
- 2023-08-22 10:54:35
- date last changed
- 2024-04-20 01:12:54
@article{745e029d-e306-4d8b-b82b-9ee4ff8411de,
abstract = {{<p>Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into—and generate evolutionary hypotheses on—the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the immunome concept, a framework for characterizing genes involved in immune defence from a comparative perspective, then we outline how immune genes of interest can be identified. Second, we focus on how different selection modes are observed acting across groups of immune genes and propose hypotheses to explain these differences. We then provide an overview of the approaches used so far to study the evolutionary heterogeneity of immune genes on macro and microevolutionary scales. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes. This review results from the collective discussion on the current key challenges in evolutionary immunology conducted at the ESEB 2021 Online Satellite Symposium: Molecular evolution of the vertebrate immune system, from the lab to natural populations.</p>}},
author = {{Vinkler, Michal and Fiddaman, Steven R. and Těšický, Martin and O'Connor, Emily A. and Savage, Anna E. and Lenz, Tobias L. and Smith, Adrian L. and Kaufman, Jim and Bolnick, Daniel I. and Davies, Charli S. and Dedić, Neira and Flies, Andrew S. and Samblás, M. Mercedes Gómez and Henschen, Amberleigh E. and Novák, Karel and Palomar, Gemma and Raven, Nynke and Samaké, Kalifa and Slade, Joel and Veetil, Nithya Kuttiyarthu and Voukali, Eleni and Höglund, Jacob and Richardson, David S. and Westerdahl, Helena}},
issn = {{1010-061X}},
keywords = {{adaptation; adaptive immunity; evolutionary immunology; genomics; host-parasite interactions; immunogenetics; innate immunity; MHC; molecular evolution; vertebrates}},
language = {{eng}},
number = {{6}},
pages = {{847--873}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of evolutionary biology}},
title = {{Understanding the evolution of immune genes in jawed vertebrates}},
url = {{http://dx.doi.org/10.1111/jeb.14181}},
doi = {{10.1111/jeb.14181}},
volume = {{36}},
year = {{2023}},
}