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DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

Chouliaras, Leonidas; Kenis, Gunter; Visser, Pieter Jelle; Scheltens, Philip; Tsolaki, Magda; Jones, Roy W; Kehoe, Patrick G; Graff, Caroline; Girtler, Nicola G and Wallin, Åsa LU , et al. (2015) In Epigenomics 7(4). p.533-537
Abstract
Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
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type
Contribution to journal
publication status
published
subject
in
Epigenomics
volume
7
issue
4
pages
533 - 537
publisher
Future Medicine Ltd.
external identifiers
  • pmid:26111027
  • wos:000356885200004
  • scopus:84933505719
ISSN
1750-192X
DOI
10.2217/epi.15.22
language
English
LU publication?
yes
id
50121327-ae33-47c5-913f-b2d3e6299938 (old id 7477911)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26111027?dopt=Abstract
date added to LUP
2015-07-10 22:46:45
date last changed
2017-07-09 03:18:47
@article{50121327-ae33-47c5-913f-b2d3e6299938,
  abstract     = {Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.},
  author       = {Chouliaras, Leonidas and Kenis, Gunter and Visser, Pieter Jelle and Scheltens, Philip and Tsolaki, Magda and Jones, Roy W and Kehoe, Patrick G and Graff, Caroline and Girtler, Nicola G and Wallin, Åsa and Rikkert, Marcel Olde and Spiru, Luiza and Elias-Sonnenschein, Lyzel S and Ramakers, Inez Hgb and Pishva, Ehsan and Os, Jim van and Steinbusch, Harry Wm and Verhey, Frans Rj and van den Hove, Daniel LA and Rutten, Bart Pf},
  issn         = {1750-192X},
  language     = {eng},
  number       = {4},
  pages        = {533--537},
  publisher    = {Future Medicine Ltd.},
  series       = {Epigenomics},
  title        = {DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.},
  url          = {http://dx.doi.org/10.2217/epi.15.22},
  volume       = {7},
  year         = {2015},
}