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New developments in the pathogenesis of obesity-induced hypertension.

Kotsis, Vasilios; Nilsson, Peter LU ; Grassi, Guido; Mancia, Giuseppe LU ; Redon, Josep; Luft, Frank; Schmieder, Roland; Engeli, Stefan; Stabouli, Stella and Antza, Christina, et al. (2015) In Journal of Hypertension 33(8). p.1499-1508
Abstract
Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hypertension, many obese individuals may not develop hypertension. Protecting factors may exist and it is important to understand why obesity is not always related to hypertension. The aim of this review is to highlight the knowledge gap for the association between obesity, hypertension, and potential genetic and racial differences or environmental... (More)
Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hypertension, many obese individuals may not develop hypertension. Protecting factors may exist and it is important to understand why obesity is not always related to hypertension. The aim of this review is to highlight the knowledge gap for the association between obesity, hypertension, and potential genetic and racial differences or environmental factors that may protect obese patients against the development of hypertension and other co-morbidities. Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity. Furthermore, gene-environment interactions may have the potential to modify gene expression and epigenetic mechanisms could also contribute to the heritability of obesity-induced hypertension. Finally, differences in nutrition, gut microbiota, exposure to sun light and exercise may play an important role in the presence or absence of hypertension in obesity. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
33
issue
8
pages
1499 - 1508
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:26103132
  • wos:000360853900002
  • scopus:84941209260
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000645
language
English
LU publication?
yes
id
7311df3d-f770-40e3-a60e-906ab0f80b3e (old id 7478147)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26103132?dopt=Abstract
date added to LUP
2015-07-10 21:33:20
date last changed
2017-08-27 03:31:29
@article{7311df3d-f770-40e3-a60e-906ab0f80b3e,
  abstract     = {Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hypertension, many obese individuals may not develop hypertension. Protecting factors may exist and it is important to understand why obesity is not always related to hypertension. The aim of this review is to highlight the knowledge gap for the association between obesity, hypertension, and potential genetic and racial differences or environmental factors that may protect obese patients against the development of hypertension and other co-morbidities. Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity. Furthermore, gene-environment interactions may have the potential to modify gene expression and epigenetic mechanisms could also contribute to the heritability of obesity-induced hypertension. Finally, differences in nutrition, gut microbiota, exposure to sun light and exercise may play an important role in the presence or absence of hypertension in obesity.},
  author       = {Kotsis, Vasilios and Nilsson, Peter and Grassi, Guido and Mancia, Giuseppe and Redon, Josep and Luft, Frank and Schmieder, Roland and Engeli, Stefan and Stabouli, Stella and Antza, Christina and Pall, Denes and Schlaich, Markus and Jordan, Jens},
  issn         = {1473-5598},
  language     = {eng},
  number       = {8},
  pages        = {1499--1508},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {New developments in the pathogenesis of obesity-induced hypertension.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000645},
  volume       = {33},
  year         = {2015},
}