Dynamics of Cell Generation and Turnover in the Human Heart.
(2015) In Cell 161(7). p.1566-1575- Abstract
- The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood,... (More)
- The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7486280
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell
- volume
- 161
- issue
- 7
- pages
- 1566 - 1575
- publisher
- Cell Press
- external identifiers
-
- pmid:26073943
- wos:000356618200014
- scopus:84931571363
- pmid:26073943
- ISSN
- 1097-4172
- DOI
- 10.1016/j.cell.2015.05.026
- language
- English
- LU publication?
- yes
- id
- 608ddda0-e244-4d55-b6c4-c9d238e7fb73 (old id 7486280)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26073943?dopt=Abstract
- date added to LUP
- 2016-04-01 10:23:09
- date last changed
- 2022-08-27 08:44:38
@article{608ddda0-e244-4d55-b6c4-c9d238e7fb73, abstract = {{The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT.}}, author = {{Bergmann, Olaf and Zdunek, Sofia and Felker, Anastasia and Salehpour, Mehran and Alkass, Kanar and Bernard, Samuel and Sjostrom, Staffan L and Szewczykowska, Mirosława and Jackowska, Teresa and Dos Remedios, Cris and Malm, Torsten and Andrä, Michaela and Jashari, Ramadan and Nyengaard, Jens R and Possnert, Göran and Jovinge, Stefan and Druid, Henrik and Frisén, Jonas}}, issn = {{1097-4172}}, language = {{eng}}, number = {{7}}, pages = {{1566--1575}}, publisher = {{Cell Press}}, series = {{Cell}}, title = {{Dynamics of Cell Generation and Turnover in the Human Heart.}}, url = {{http://dx.doi.org/10.1016/j.cell.2015.05.026}}, doi = {{10.1016/j.cell.2015.05.026}}, volume = {{161}}, year = {{2015}}, }