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Dynamics of Cell Generation and Turnover in the Human Heart.

Bergmann, Olaf; Zdunek, Sofia; Felker, Anastasia; Salehpour, Mehran; Alkass, Kanar; Bernard, Samuel; Sjostrom, Staffan L; Szewczykowska, Mirosława; Jackowska, Teresa and Dos Remedios, Cris, et al. (2015) In Cell 161(7). p.1566-1575
Abstract
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood,... (More)
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT. (Less)
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publication status
published
subject
in
Cell
volume
161
issue
7
pages
1566 - 1575
publisher
Cell Press
external identifiers
  • pmid:26073943
  • wos:000356618200014
  • scopus:84931571363
ISSN
1097-4172
DOI
10.1016/j.cell.2015.05.026
language
English
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yes
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608ddda0-e244-4d55-b6c4-c9d238e7fb73 (old id 7486280)
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http://www.ncbi.nlm.nih.gov/pubmed/26073943?dopt=Abstract
date added to LUP
2015-07-08 13:40:06
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2017-11-19 03:09:55
@article{608ddda0-e244-4d55-b6c4-c9d238e7fb73,
  abstract     = {The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (&gt;15% per year) and more limited renewal of mesenchymal cells (&lt;4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to &lt;1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT.},
  author       = {Bergmann, Olaf and Zdunek, Sofia and Felker, Anastasia and Salehpour, Mehran and Alkass, Kanar and Bernard, Samuel and Sjostrom, Staffan L and Szewczykowska, Mirosława and Jackowska, Teresa and Dos Remedios, Cris and Malm, Torsten and Andrä, Michaela and Jashari, Ramadan and Nyengaard, Jens R and Possnert, Göran and Jovinge, Stefan and Druid, Henrik and Frisén, Jonas},
  issn         = {1097-4172},
  language     = {eng},
  number       = {7},
  pages        = {1566--1575},
  publisher    = {Cell Press},
  series       = {Cell},
  title        = {Dynamics of Cell Generation and Turnover in the Human Heart.},
  url          = {http://dx.doi.org/10.1016/j.cell.2015.05.026},
  volume       = {161},
  year         = {2015},
}