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Non-Viral Deoxyribonucleoside Kinases - Diversity and Practical Use

Slot Christiansen, Louise LU ; Munch-Petersen, Birgitte LU and Knecht, Wolfgang LU (2015) In Journal of Genetics and Genomics 42(5). p.235-248
Abstract
Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and... (More)
Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nucleosides, Nucleotides, Nucleoside salvage pathway, Evolution, Suicide, gene therapy, Deoxynucleosides, Deoxynucleotides, Deoxynucleoside, kinases
in
Journal of Genetics and Genomics
volume
42
issue
5
pages
235 - 248
publisher
Science Press
external identifiers
  • pmid:26059771
  • wos:000355743500006
  • scopus:84947034021
ISSN
1673-8527
DOI
10.1016/j.jgg.2015.01.003
language
English
LU publication?
yes
id
a61c2587-c1aa-40fc-9755-0eae5ed1cfd3 (old id 7487159)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26059771?dopt=Abstract
date added to LUP
2015-07-22 09:18:24
date last changed
2017-09-10 03:11:47
@article{a61c2587-c1aa-40fc-9755-0eae5ed1cfd3,
  abstract     = {Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.},
  author       = {Slot Christiansen, Louise and Munch-Petersen, Birgitte and Knecht, Wolfgang},
  issn         = {1673-8527},
  keyword      = {Nucleosides,Nucleotides,Nucleoside salvage pathway,Evolution,Suicide,gene therapy,Deoxynucleosides,Deoxynucleotides,Deoxynucleoside,kinases},
  language     = {eng},
  number       = {5},
  pages        = {235--248},
  publisher    = {Science Press},
  series       = {Journal of Genetics and Genomics},
  title        = {Non-Viral Deoxyribonucleoside Kinases - Diversity and Practical Use},
  url          = {http://dx.doi.org/10.1016/j.jgg.2015.01.003},
  volume       = {42},
  year         = {2015},
}