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Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

Bhattachariya, Anirban LU ; Dahan, Diana LU ; Ekman, Mari LU ; Boettger, T; Braun, T; Swärd, Karl LU ; Hellstrand, Per LU and Albinsson, Sebastian LU (2015) In Acta Physiologica 215(3). p.133-143
Abstract
Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
volume
215
issue
3
pages
133 - 143
publisher
Wiley-Blackwell
external identifiers
  • pmid:26052659
  • wos:000362894200006
  • scopus:84943579848
ISSN
1748-1708
DOI
10.1111/apha.12536
language
English
LU publication?
yes
id
27a985e4-3fd7-47df-8d32-295ed9c78d1a (old id 7487582)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26052659?dopt=Abstract
date added to LUP
2015-07-07 13:19:29
date last changed
2017-10-01 03:10:31
@article{27a985e4-3fd7-47df-8d32-295ed9c78d1a,
  abstract     = {Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.},
  author       = {Bhattachariya, Anirban and Dahan, Diana and Ekman, Mari and Boettger, T and Braun, T and Swärd, Karl and Hellstrand, Per and Albinsson, Sebastian},
  issn         = {1748-1708},
  language     = {eng},
  number       = {3},
  pages        = {133--143},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica},
  title        = {Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.},
  url          = {http://dx.doi.org/10.1111/apha.12536},
  volume       = {215},
  year         = {2015},
}