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Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI.

Degerman, Eva LU ; in 't Zandt, René LU ; Holmén-Pålbrink, Ann-Kristin LU and Magnusson, Måns LU (2015) In Hearing Research 330(Part A). p.119-124
Abstract
From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play a critical role in endolymph homeostasis and may be involved in the development of Ménière's disease. In this study we evaluate the effect of vasopressin administration in vivo in longitudinal studies using two mouse strains. High resolution MRI at 9.4 T in combination with intraperitoneally delivered Gadolinium contrast, was performed before and after chronic subcutaneous administration of vasopressin via mini-osmotic pumps in the same mouse. A development of endolymphatic hydrops over time... (More)
From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play a critical role in endolymph homeostasis and may be involved in the development of Ménière's disease. In this study we evaluate the effect of vasopressin administration in vivo in longitudinal studies using two mouse strains. High resolution MRI at 9.4 T in combination with intraperitoneally delivered Gadolinium contrast, was performed before and after chronic subcutaneous administration of vasopressin via mini-osmotic pumps in the same mouse. A development of endolymphatic hydrops over time could be demonstrated in C57BL6 mice (5 mice, 2 and 4 weeks of administration) as well as in CBA/J mice (4 mice, 2 weeks of administration; 6 mice, 3 and 4 weeks of administration). In most C57BL6 mice hydrops developed first after more than 2 weeks while CBA/J mice had an earlier response. These results may suggest an in vivo model for studying endolymphatic hydrops and corroborates the future use of MRI as a tool in the diagnosis and treatment of inner ear diseases, such as Ménière's disease. MRI may also be developed as a critical tool in evaluating inner ear homeostasis in genetically modified mice, to augment the understanding of human disease. This article is part of a Special Issue entitled <IEB Kyoto>. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hearing Research
volume
330
issue
Part A
pages
119 - 124
publisher
Elsevier
external identifiers
  • pmid:26048336
  • wos:000367492100015
  • scopus:84949093802
ISSN
0378-5955
DOI
10.1016/j.heares.2015.05.008
language
English
LU publication?
yes
id
e68250cb-bf7b-4648-9e54-97ac2d44b27e (old id 7487950)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26048336?dopt=Abstract
date added to LUP
2015-07-07 11:18:13
date last changed
2017-04-23 03:24:01
@article{e68250cb-bf7b-4648-9e54-97ac2d44b27e,
  abstract     = {From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play a critical role in endolymph homeostasis and may be involved in the development of Ménière's disease. In this study we evaluate the effect of vasopressin administration in vivo in longitudinal studies using two mouse strains. High resolution MRI at 9.4 T in combination with intraperitoneally delivered Gadolinium contrast, was performed before and after chronic subcutaneous administration of vasopressin via mini-osmotic pumps in the same mouse. A development of endolymphatic hydrops over time could be demonstrated in C57BL6 mice (5 mice, 2 and 4 weeks of administration) as well as in CBA/J mice (4 mice, 2 weeks of administration; 6 mice, 3 and 4 weeks of administration). In most C57BL6 mice hydrops developed first after more than 2 weeks while CBA/J mice had an earlier response. These results may suggest an in vivo model for studying endolymphatic hydrops and corroborates the future use of MRI as a tool in the diagnosis and treatment of inner ear diseases, such as Ménière's disease. MRI may also be developed as a critical tool in evaluating inner ear homeostasis in genetically modified mice, to augment the understanding of human disease. This article is part of a Special Issue entitled &lt;IEB Kyoto&gt;.},
  author       = {Degerman, Eva and in 't Zandt, René and Holmén-Pålbrink, Ann-Kristin and Magnusson, Måns},
  issn         = {0378-5955},
  language     = {eng},
  number       = {Part A},
  pages        = {119--124},
  publisher    = {Elsevier},
  series       = {Hearing Research},
  title        = {Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI.},
  url          = {http://dx.doi.org/10.1016/j.heares.2015.05.008},
  volume       = {330},
  year         = {2015},
}