Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
(2015) In Cell Communication and Signaling 13(1).- Abstract
- Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7487998
- author
- Olsen, Oddrun Elise ; Wader, Karin Fahl ; Hella, Hanne ; Mylin, Anne Kærsgaard ; Turesson, Ingemar LU ; Nesthus, Ingerid ; Waage, Anders ; Sundan, Anders and Holien, Toril
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Communication and Signaling
- volume
- 13
- issue
- 1
- article number
- 27
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26047946
- wos:000355968100001
- scopus:84931048536
- pmid:26047946
- ISSN
- 1478-811X
- DOI
- 10.1186/s12964-015-0104-z
- language
- English
- LU publication?
- yes
- id
- 83a07623-42b2-4749-8668-5cba28aefc66 (old id 7487998)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26047946?dopt=Abstract
- date added to LUP
- 2016-04-01 13:20:19
- date last changed
- 2024-10-10 00:58:48
@article{83a07623-42b2-4749-8668-5cba28aefc66, abstract = {{Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.}}, author = {{Olsen, Oddrun Elise and Wader, Karin Fahl and Hella, Hanne and Mylin, Anne Kærsgaard and Turesson, Ingemar and Nesthus, Ingerid and Waage, Anders and Sundan, Anders and Holien, Toril}}, issn = {{1478-811X}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Cell Communication and Signaling}}, title = {{Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.}}, url = {{https://lup.lub.lu.se/search/files/3311596/8776806}}, doi = {{10.1186/s12964-015-0104-z}}, volume = {{13}}, year = {{2015}}, }