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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

Olsen, Oddrun Elise ; Wader, Karin Fahl ; Hella, Hanne ; Mylin, Anne Kærsgaard ; Turesson, Ingemar LU ; Nesthus, Ingerid ; Waage, Anders ; Sundan, Anders and Holien, Toril (2015) In Cell Communication and Signaling 13(1).
Abstract
Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Communication and Signaling
volume
13
issue
1
article number
27
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26047946
  • wos:000355968100001
  • scopus:84931048536
  • pmid:26047946
ISSN
1478-811X
DOI
10.1186/s12964-015-0104-z
language
English
LU publication?
yes
id
83a07623-42b2-4749-8668-5cba28aefc66 (old id 7487998)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26047946?dopt=Abstract
date added to LUP
2016-04-01 13:20:19
date last changed
2024-10-10 00:58:48
@article{83a07623-42b2-4749-8668-5cba28aefc66,
  abstract     = {{Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.}},
  author       = {{Olsen, Oddrun Elise and Wader, Karin Fahl and Hella, Hanne and Mylin, Anne Kærsgaard and Turesson, Ingemar and Nesthus, Ingerid and Waage, Anders and Sundan, Anders and Holien, Toril}},
  issn         = {{1478-811X}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Cell Communication and Signaling}},
  title        = {{Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.}},
  url          = {{https://lup.lub.lu.se/search/files/3311596/8776806}},
  doi          = {{10.1186/s12964-015-0104-z}},
  volume       = {{13}},
  year         = {{2015}},
}