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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne Kærsgaard; Turesson, Ingemar LU ; Nesthus, Ingerid; Waage, Anders; Sundan, Anders and Holien, Toril (2015) In Cell Communication and Signaling 13(1).
Abstract
Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Communication and Signaling
volume
13
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26047946
  • wos:000355968100001
  • scopus:84931048536
ISSN
1478-811X
DOI
10.1186/s12964-015-0104-z
language
English
LU publication?
yes
id
83a07623-42b2-4749-8668-5cba28aefc66 (old id 7487998)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26047946?dopt=Abstract
date added to LUP
2015-07-07 11:23:11
date last changed
2017-10-01 04:06:28
@article{83a07623-42b2-4749-8668-5cba28aefc66,
  abstract     = {Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.},
  articleno    = {27},
  author       = {Olsen, Oddrun Elise and Wader, Karin Fahl and Hella, Hanne and Mylin, Anne Kærsgaard and Turesson, Ingemar and Nesthus, Ingerid and Waage, Anders and Sundan, Anders and Holien, Toril},
  issn         = {1478-811X},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Cell Communication and Signaling},
  title        = {Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.},
  url          = {http://dx.doi.org/10.1186/s12964-015-0104-z},
  volume       = {13},
  year         = {2015},
}