Hydrolysis of chylomicron retinyl ester by an acid retinyl esterase of rat liver
(1983) In Biochimica et Biophysica Acta 751(3). p.474-478- Abstract (Swedish)
- Rat liver homogenate hydrolyzed chylomicron remnant retinyl esters with pH optima 4.5, 6 and 8. The retinyl ester hydrolysis at pH 4.5 was correlated to the acid phosphatase activity in different subcellular fractions, and thus the highest activity was found in highly purified lysosomes. These fractions could also catalyze the reverse reaction, i.e., the esterification of retinol when incubated with excess palmitic acid. Purified rat liver lysosomes hydrolyzed chylomicron retinyl and cholesteryl esters with comparable rates, both being much lower than the hydrolysis of chylomicron triacylglycerols.
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https://lup.lub.lu.se/record/74a51187-f948-426a-83d2-e5d2b2643b56
- author
- Larsson, Britta and Nilsson, Åke LU
- publishing date
- 1983-05-01
- type
- Contribution to journal
- publication status
- published
- in
- Biochimica et Biophysica Acta
- volume
- 751
- issue
- 3
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:6849957
- scopus:0020631036
- ISSN
- 0006-3002
- language
- Swedish
- LU publication?
- no
- id
- 74a51187-f948-426a-83d2-e5d2b2643b56
- date added to LUP
- 2019-05-26 09:43:02
- date last changed
- 2021-12-19 04:01:16
@article{74a51187-f948-426a-83d2-e5d2b2643b56, abstract = {{Rat liver homogenate hydrolyzed chylomicron remnant retinyl esters with pH optima 4.5, 6 and 8. The retinyl ester hydrolysis at pH 4.5 was correlated to the acid phosphatase activity in different subcellular fractions, and thus the highest activity was found in highly purified lysosomes. These fractions could also catalyze the reverse reaction, i.e., the esterification of retinol when incubated with excess palmitic acid. Purified rat liver lysosomes hydrolyzed chylomicron retinyl and cholesteryl esters with comparable rates, both being much lower than the hydrolysis of chylomicron triacylglycerols.}}, author = {{Larsson, Britta and Nilsson, Åke}}, issn = {{0006-3002}}, language = {{swe}}, month = {{05}}, number = {{3}}, pages = {{474--478}}, publisher = {{Elsevier}}, series = {{Biochimica et Biophysica Acta}}, title = {{Hydrolysis of chylomicron retinyl ester by an acid retinyl esterase of rat liver}}, volume = {{751}}, year = {{1983}}, }