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Hydrolysis of chylomicron retinyl ester by an acid retinyl esterase of rat liver

Larsson, Britta and Nilsson, Åke LU (1983) In Biochimica et Biophysica Acta 751(3). p.474-478
Abstract (Swedish)
Rat liver homogenate hydrolyzed chylomicron remnant retinyl esters with pH optima 4.5, 6 and 8. The retinyl ester hydrolysis at pH 4.5 was correlated to the acid phosphatase activity in different subcellular fractions, and thus the highest activity was found in highly purified lysosomes. These fractions could also catalyze the reverse reaction, i.e., the esterification of retinol when incubated with excess palmitic acid. Purified rat liver lysosomes hydrolyzed chylomicron retinyl and cholesteryl esters with comparable rates, both being much lower than the hydrolysis of chylomicron triacylglycerols.
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author
and
publishing date
type
Contribution to journal
publication status
published
in
Biochimica et Biophysica Acta
volume
751
issue
3
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:6849957
  • scopus:0020631036
ISSN
0006-3002
language
Swedish
LU publication?
no
id
74a51187-f948-426a-83d2-e5d2b2643b56
date added to LUP
2019-05-26 09:43:02
date last changed
2021-12-19 04:01:16
@article{74a51187-f948-426a-83d2-e5d2b2643b56,
  abstract     = {{Rat liver homogenate hydrolyzed chylomicron remnant retinyl esters with pH optima 4.5, 6 and 8. The retinyl ester hydrolysis at pH 4.5 was correlated to the acid phosphatase activity in different subcellular fractions, and thus the highest activity was found in highly purified lysosomes. These fractions could also catalyze the reverse reaction, i.e., the esterification of retinol when incubated with excess palmitic acid. Purified rat liver lysosomes hydrolyzed chylomicron retinyl and cholesteryl esters with comparable rates, both being much lower than the hydrolysis of chylomicron triacylglycerols.}},
  author       = {{Larsson, Britta and Nilsson, Åke}},
  issn         = {{0006-3002}},
  language     = {{swe}},
  month        = {{05}},
  number       = {{3}},
  pages        = {{474--478}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Hydrolysis of chylomicron retinyl ester by an acid retinyl esterase of rat liver}},
  volume       = {{751}},
  year         = {{1983}},
}