Real-time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways
(2022) In Magnetic Resonance in Medicine 88(2). p.770-786- Abstract
Purpose: Respiration-related CSF flow through the cerebral aqueduct may be useful for elucidating physiology and pathophysiology of the glymphatic system, which has been proposed as a mechanism of brain waste clearance. Therefore, we aimed to (1) develop a real-time (CSF) flow imaging method with high spatial and sufficient temporal resolution to capture respiratory effects, (2) validate the method in a phantom setup and numerical simulations, and (3) apply the method in vivo and quantify its repeatability and correlation with different respiratory conditions. Methods: A golden-angle radial flow sequence (reconstructed temporal resolution 168 ms, spatial resolution 0.6 mm) was implemented on a 7T MRI scanner and reconstructed using... (More)
Purpose: Respiration-related CSF flow through the cerebral aqueduct may be useful for elucidating physiology and pathophysiology of the glymphatic system, which has been proposed as a mechanism of brain waste clearance. Therefore, we aimed to (1) develop a real-time (CSF) flow imaging method with high spatial and sufficient temporal resolution to capture respiratory effects, (2) validate the method in a phantom setup and numerical simulations, and (3) apply the method in vivo and quantify its repeatability and correlation with different respiratory conditions. Methods: A golden-angle radial flow sequence (reconstructed temporal resolution 168 ms, spatial resolution 0.6 mm) was implemented on a 7T MRI scanner and reconstructed using compressed sensing. A phantom setup mimicked simultaneous cardiac and respiratory flow oscillations. The effect of temporal resolution and vessel diameter was investigated numerically. Healthy volunteers (n = 10) were scanned at four different respiratory conditions, including repeat scans. Results: Phantom data show that the developed sequence accurately quantifies respiratory oscillations (ratio real-time/reference QR = 0.96 ± 0.02), but underestimates the rapid cardiac oscillations (ratio QC = 0.46 ± 0.14). Simulations suggest that QC can be improved by increasing temporal resolution. In vivo repeatability was moderate to very strong for cranial and caudal flow (intraclass correlation coefficient range: 0.55–0.99) and weak to strong for net flow (intraclass correlation coefficient range: 0.48–0.90). Net flow was influenced by respiratory condition (p < 0.01). Conclusions: The presented real-time flow MRI method can quantify respiratory-related variations of CSF flow in the cerebral aqueduct, but it underestimates rapid cardiac oscillations. In vivo, the method showed good repeatability and a relationship between flow and respiration.
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- author
- Töger, Johannes LU ; Andersen, Mads LU ; Haglund, Olle ; Kylkilahti, Tekla Maria LU ; Lundgaard, Iben LU and Markenroth Bloch, Karin LU
- organization
-
- Clinical Physiology (Lund)
- Lund Cardiac MR Group (research group)
- MR Physics (research group)
- eSSENCE: The e-Science Collaboration
- Lund University Bioimaging Center
- WCMM-Wallenberg Centre for Molecular Medicine
- Glia-Immune Interactions (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebrospinal fluid, CSF, flow, magnetic resonance imaging, MRI, real-time
- in
- Magnetic Resonance in Medicine
- volume
- 88
- issue
- 2
- pages
- 17 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85127771975
- pmid:35403247
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.29248
- language
- English
- LU publication?
- yes
- id
- 74d6c3ee-ad78-4130-b0f8-dd98bcb4f2ea
- date added to LUP
- 2022-06-28 13:43:25
- date last changed
- 2024-09-18 14:48:23
@article{74d6c3ee-ad78-4130-b0f8-dd98bcb4f2ea, abstract = {{<p>Purpose: Respiration-related CSF flow through the cerebral aqueduct may be useful for elucidating physiology and pathophysiology of the glymphatic system, which has been proposed as a mechanism of brain waste clearance. Therefore, we aimed to (1) develop a real-time (CSF) flow imaging method with high spatial and sufficient temporal resolution to capture respiratory effects, (2) validate the method in a phantom setup and numerical simulations, and (3) apply the method in vivo and quantify its repeatability and correlation with different respiratory conditions. Methods: A golden-angle radial flow sequence (reconstructed temporal resolution 168 ms, spatial resolution 0.6 mm) was implemented on a 7T MRI scanner and reconstructed using compressed sensing. A phantom setup mimicked simultaneous cardiac and respiratory flow oscillations. The effect of temporal resolution and vessel diameter was investigated numerically. Healthy volunteers (n = 10) were scanned at four different respiratory conditions, including repeat scans. Results: Phantom data show that the developed sequence accurately quantifies respiratory oscillations (ratio real-time/reference Q<sub>R</sub> = 0.96 ± 0.02), but underestimates the rapid cardiac oscillations (ratio Q<sub>C</sub> = 0.46 ± 0.14). Simulations suggest that Q<sub>C</sub> can be improved by increasing temporal resolution. In vivo repeatability was moderate to very strong for cranial and caudal flow (intraclass correlation coefficient range: 0.55–0.99) and weak to strong for net flow (intraclass correlation coefficient range: 0.48–0.90). Net flow was influenced by respiratory condition (p < 0.01). Conclusions: The presented real-time flow MRI method can quantify respiratory-related variations of CSF flow in the cerebral aqueduct, but it underestimates rapid cardiac oscillations. In vivo, the method showed good repeatability and a relationship between flow and respiration.</p>}}, author = {{Töger, Johannes and Andersen, Mads and Haglund, Olle and Kylkilahti, Tekla Maria and Lundgaard, Iben and Markenroth Bloch, Karin}}, issn = {{0740-3194}}, keywords = {{cerebrospinal fluid; CSF; flow; magnetic resonance imaging; MRI; real-time}}, language = {{eng}}, number = {{2}}, pages = {{770--786}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Magnetic Resonance in Medicine}}, title = {{Real-time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways}}, url = {{http://dx.doi.org/10.1002/mrm.29248}}, doi = {{10.1002/mrm.29248}}, volume = {{88}}, year = {{2022}}, }