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Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease

Bacci, Julia R ; Karagianni, Stamatia ; Alexopoulou, Zampeta-Sofia ; Moukaled, Shirine ; Tato-Fernández, Claudia ; Arunachalam, Prithvi ; Aslanyan, Aram ; Aye, Sandar ; Rocha, Ana Sabsil Lopez and Crugel, Monica , et al. (2026) In Alzheimer's Research & Therapy 18(1).
Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities and are being increasingly used in clinical settings to aid diagnosis, monitor disease progression, and assess eligibility and response to disease-modifying therapies. Here, we provide an overview of current clinical applications of fluid, imaging, and digital biomarkers for AD. We also discuss biomarkers under development and challenges... (More)

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities and are being increasingly used in clinical settings to aid diagnosis, monitor disease progression, and assess eligibility and response to disease-modifying therapies. Here, we provide an overview of current clinical applications of fluid, imaging, and digital biomarkers for AD. We also discuss biomarkers under development and challenges associated with the implementation of these modalities in clinical settings.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's Research & Therapy
volume
18
issue
1
article number
14
publisher
BioMed Central (BMC)
external identifiers
  • pmid:41508141
ISSN
1758-9193
DOI
10.1186/s13195-025-01921-5
language
English
LU publication?
yes
id
74ee0ca7-56d8-458d-b656-b65660b7b364
date added to LUP
2026-01-20 16:38:31
date last changed
2026-01-20 16:39:44
@article{74ee0ca7-56d8-458d-b656-b65660b7b364,
  abstract     = {{<p>Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities and are being increasingly used in clinical settings to aid diagnosis, monitor disease progression, and assess eligibility and response to disease-modifying therapies. Here, we provide an overview of current clinical applications of fluid, imaging, and digital biomarkers for AD. We also discuss biomarkers under development and challenges associated with the implementation of these modalities in clinical settings.</p>}},
  author       = {{Bacci, Julia R and Karagianni, Stamatia and Alexopoulou, Zampeta-Sofia and Moukaled, Shirine and Tato-Fernández, Claudia and Arunachalam, Prithvi and Aslanyan, Aram and Aye, Sandar and Rocha, Ana Sabsil Lopez and Crugel, Monica and Fawad, Ayesha and Sogorb-Esteve, Aitana and Schöll, Michael and König, Alexandra and Paterson, Ross W}},
  issn         = {{1758-9193}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Alzheimer's Research & Therapy}},
  title        = {{Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1186/s13195-025-01921-5}},
  doi          = {{10.1186/s13195-025-01921-5}},
  volume       = {{18}},
  year         = {{2026}},
}