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Environmental Risk Factors for Parkinson's Disease : A Critical Review and Policy Implications

Atterling Brolin, Kajsa LU orcid ; Schaeffer, Eva ; Kuri, Ashvin ; Rumrich, Isabell Katharina ; Schumacher Schuh, Artur Francisco ; Darweesh, Sirwan K L ; Kaasinen, Valtteri ; Tolppanen, Anna-Maija ; Chahine, Lana M and Noyce, Alastair J (2024) In Movement Disorders p.1-18
Abstract

The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported to be associated with PD, in particular pesticides, trichloroethylene (TCE), and air pollution. In this review we critically evaluate the epidemiological and biological evidence on the associations of these factors with PD and review evidence on whether these putative associations are causal. We conclude that when considered in isolation, it... (More)

The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported to be associated with PD, in particular pesticides, trichloroethylene (TCE), and air pollution. In this review we critically evaluate the epidemiological and biological evidence on the associations of these factors with PD and review evidence on whether these putative associations are causal. We conclude that when considered in isolation, it is difficult to determine whether these associations are causal, in large part because of the decades-long lag between relevant exposures and the incidence of manifest PD. However, when considered in tandem with evidence from complementary research lines (such as animal models), it is increasingly likely that these associations reflect harmful causal effects. Fundamentally, whilst we highlight some evidence gaps that require further attention, we believe the current evidence base is sufficiently strong enough to support our call for stronger policy action. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Movement Disorders
pages
1 - 18
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85210408880
  • pmid:39601461
ISSN
0885-3185
DOI
10.1002/mds.30067
language
English
LU publication?
yes
additional info
© 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
id
74f0407d-9b71-4744-8e66-1f5d46dad9bd
date added to LUP
2024-12-03 11:39:57
date last changed
2025-07-15 19:57:32
@article{74f0407d-9b71-4744-8e66-1f5d46dad9bd,
  abstract     = {{<p>The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported to be associated with PD, in particular pesticides, trichloroethylene (TCE), and air pollution. In this review we critically evaluate the epidemiological and biological evidence on the associations of these factors with PD and review evidence on whether these putative associations are causal. We conclude that when considered in isolation, it is difficult to determine whether these associations are causal, in large part because of the decades-long lag between relevant exposures and the incidence of manifest PD. However, when considered in tandem with evidence from complementary research lines (such as animal models), it is increasingly likely that these associations reflect harmful causal effects. Fundamentally, whilst we highlight some evidence gaps that require further attention, we believe the current evidence base is sufficiently strong enough to support our call for stronger policy action. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p>}},
  author       = {{Atterling Brolin, Kajsa and Schaeffer, Eva and Kuri, Ashvin and Rumrich, Isabell Katharina and Schumacher Schuh, Artur Francisco and Darweesh, Sirwan K L and Kaasinen, Valtteri and Tolppanen, Anna-Maija and Chahine, Lana M and Noyce, Alastair J}},
  issn         = {{0885-3185}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{1--18}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders}},
  title        = {{Environmental Risk Factors for Parkinson's Disease : A Critical Review and Policy Implications}},
  url          = {{http://dx.doi.org/10.1002/mds.30067}},
  doi          = {{10.1002/mds.30067}},
  year         = {{2024}},
}