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Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma

Budde, Axel ; Baust, Katja ; Weinhold, Leonie ; Bernstein, Mark ; Bielack, Stefan ; Dhooge, Catharina ; Hjorth, Lars LU ; Janeway, Katherine A. ; Jenney, Meriel and Krailo, Mark D. , et al. (2022) In European Journal of Cancer 170. p.209-235
Abstract

Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures. Method: To this end, we linked physical functioning scores from the Paediatric Quality of Life Inventory (PedsQL) and the Paediatric Quality of Life Questionnaire (PEDQOL) to the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) for adults. Samples from the EURAMOS-1 QoL sub-study of 75 (PedsQL) and... (More)

Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures. Method: To this end, we linked physical functioning scores from the Paediatric Quality of Life Inventory (PedsQL) and the Paediatric Quality of Life Questionnaire (PEDQOL) to the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) for adults. Samples from the EURAMOS-1 QoL sub-study of 75 (PedsQL) and 112 (PEDQOL) adolescent osteosarcoma patients were concurrently administered both paediatric and adult questionnaires on 98 (PedsQL) and 156 (PEDQOL) occasions. We identified corresponding scores using the single-group equipercentile linking method. Results: Linked physical functioning scores showed sufficient concordance to the EORTC QLQ-C30: Lin's ρ = 0.74 (PedsQL) and Lin's ρ = 0.64 (PEDQOL). Conclusion: Score linking provides clinicians and researchers with a common metric for assessing QoL with PRO measures across the entire lifespan of patients.

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type
Contribution to journal
publication status
published
subject
keywords
Childhood cancer, EORTC QLQ-C30, Paediatric quality of life inventory (PedsQL), Paediatric quality of life questionnaire (PEDQOL), Patient-reported outcome (PRO), Physical functioning quality-of-life (QoL), Score linking
in
European Journal of Cancer
volume
170
pages
27 pages
publisher
Elsevier
external identifiers
  • scopus:85131940609
  • pmid:35689897
ISSN
0959-8049
DOI
10.1016/j.ejca.2022.03.018
language
English
LU publication?
yes
id
75011a3f-7cb6-4aa7-a141-ba050c140365
date added to LUP
2022-10-10 09:35:32
date last changed
2024-06-13 12:51:52
@article{75011a3f-7cb6-4aa7-a141-ba050c140365,
  abstract     = {{<p>Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures. Method: To this end, we linked physical functioning scores from the Paediatric Quality of Life Inventory (PedsQL) and the Paediatric Quality of Life Questionnaire (PEDQOL) to the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) for adults. Samples from the EURAMOS-1 QoL sub-study of 75 (PedsQL) and 112 (PEDQOL) adolescent osteosarcoma patients were concurrently administered both paediatric and adult questionnaires on 98 (PedsQL) and 156 (PEDQOL) occasions. We identified corresponding scores using the single-group equipercentile linking method. Results: Linked physical functioning scores showed sufficient concordance to the EORTC QLQ-C30: Lin's ρ = 0.74 (PedsQL) and Lin's ρ = 0.64 (PEDQOL). Conclusion: Score linking provides clinicians and researchers with a common metric for assessing QoL with PRO measures across the entire lifespan of patients.</p>}},
  author       = {{Budde, Axel and Baust, Katja and Weinhold, Leonie and Bernstein, Mark and Bielack, Stefan and Dhooge, Catharina and Hjorth, Lars and Janeway, Katherine A. and Jenney, Meriel and Krailo, Mark D. and Marina, Neyssa and Nagarajan, Rajaram and Smeland, Sigbjørn and Sydes, Matthew R. and De Vos, Patricia and Whelan, Jeremy and Wiener, Andreas and Calaminus, Gabriele and Schmid, Matthias}},
  issn         = {{0959-8049}},
  keywords     = {{Childhood cancer; EORTC QLQ-C30; Paediatric quality of life inventory (PedsQL); Paediatric quality of life questionnaire (PEDQOL); Patient-reported outcome (PRO); Physical functioning quality-of-life (QoL); Score linking}},
  language     = {{eng}},
  pages        = {{209--235}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Cancer}},
  title        = {{Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma}},
  url          = {{http://dx.doi.org/10.1016/j.ejca.2022.03.018}},
  doi          = {{10.1016/j.ejca.2022.03.018}},
  volume       = {{170}},
  year         = {{2022}},
}