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Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma.

Heby, Margareta LU ; Elebro, Jacob LU ; Nodin, Björn LU ; Jirström, Karin LU and Eberhard, Jakob LU (2015) In BMC Clinical Pathology 15.
Abstract
Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like 1(PODXL), which is a cell-adhesion glycoprotein and stem cell marker, has been found to correlate with an aggressive tumour phenotype and adverse outcome in several cancer types. The aim of the present study was to examine the clinicopathological correlates, prognostic and predictive significance of tumour-specific PODXL expression in a retrospective cohort of pancreatic and periampullary carcinoma, morphologically divided into intestinal type (I-type) and pancreatobiliary type (PB-type) tumours.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Clinical Pathology
volume
15
publisher
BioMed Central
external identifiers
  • pmid:26028992
  • scopus:85027920549
ISSN
1472-6890
DOI
10.1186/s12907-015-0009-1
language
English
LU publication?
yes
id
2e9fbcbe-1ad4-4b9f-86fc-5a2607354038 (old id 7508613)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26028992?dopt=Abstract
date added to LUP
2015-07-05 04:40:07
date last changed
2017-11-05 04:16:09
@article{2e9fbcbe-1ad4-4b9f-86fc-5a2607354038,
  abstract     = {Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like 1(PODXL), which is a cell-adhesion glycoprotein and stem cell marker, has been found to correlate with an aggressive tumour phenotype and adverse outcome in several cancer types. The aim of the present study was to examine the clinicopathological correlates, prognostic and predictive significance of tumour-specific PODXL expression in a retrospective cohort of pancreatic and periampullary carcinoma, morphologically divided into intestinal type (I-type) and pancreatobiliary type (PB-type) tumours.},
  articleno    = {10},
  author       = {Heby, Margareta and Elebro, Jacob and Nodin, Björn and Jirström, Karin and Eberhard, Jakob},
  issn         = {1472-6890},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Clinical Pathology},
  title        = {Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma.},
  url          = {http://dx.doi.org/10.1186/s12907-015-0009-1},
  volume       = {15},
  year         = {2015},
}