Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.
(2015) In The Lancet 386(9991). p.360-368- Abstract
- The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7508712
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet
- volume
- 386
- issue
- 9991
- pages
- 360 - 368
- publisher
- Elsevier
- external identifiers
-
- pmid:26026936
- wos:000358448400025
- scopus:84937969384
- ISSN
- 1474-547X
- DOI
- 10.1016/S0140-6736(15)60860-1
- language
- English
- LU publication?
- yes
- id
- db4f97f8-0b5b-4185-a1a6-245da19bbe27 (old id 7508712)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26026936?dopt=Abstract
- date added to LUP
- 2016-04-01 09:51:06
- date last changed
- 2022-04-27 07:44:59
@article{db4f97f8-0b5b-4185-a1a6-245da19bbe27, abstract = {{The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.}}, author = {{Chapman, Kenneth R and Burdon, Jonathan G W and Piitulainen, Eeva and Sandhaus, Robert A and Seersholm, Niels and Stocks, James M and Stoel, Berend C and Huang, Liping and Yao, Zhenling and Edelman, Jonathan M and McElvaney, Noel G}}, issn = {{1474-547X}}, language = {{eng}}, number = {{9991}}, pages = {{360--368}}, publisher = {{Elsevier}}, series = {{The Lancet}}, title = {{Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.}}, url = {{http://dx.doi.org/10.1016/S0140-6736(15)60860-1}}, doi = {{10.1016/S0140-6736(15)60860-1}}, volume = {{386}}, year = {{2015}}, }