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Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.

Chapman, Kenneth R; Burdon, Jonathan G W; Piitulainen, Eeva LU ; Sandhaus, Robert A; Seersholm, Niels; Stocks, James M; Stoel, Berend C; Huang, Liping; Yao, Zhenling and Edelman, Jonathan M, et al. (2015) In The Lancet 386(9991). p.360-368
Abstract
The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.
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Contribution to journal
publication status
published
subject
in
The Lancet
volume
386
issue
9991
pages
360 - 368
publisher
Elsevier Limited
external identifiers
  • pmid:26026936
  • wos:000358448400025
  • scopus:84937969384
ISSN
1474-547X
DOI
10.1016/S0140-6736(15)60860-1
language
English
LU publication?
yes
id
db4f97f8-0b5b-4185-a1a6-245da19bbe27 (old id 7508712)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26026936?dopt=Abstract
date added to LUP
2015-07-05 03:19:51
date last changed
2017-11-19 03:00:56
@article{db4f97f8-0b5b-4185-a1a6-245da19bbe27,
  abstract     = {The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.},
  author       = {Chapman, Kenneth R and Burdon, Jonathan G W and Piitulainen, Eeva and Sandhaus, Robert A and Seersholm, Niels and Stocks, James M and Stoel, Berend C and Huang, Liping and Yao, Zhenling and Edelman, Jonathan M and McElvaney, Noel G},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9991},
  pages        = {360--368},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.},
  url          = {http://dx.doi.org/10.1016/S0140-6736(15)60860-1},
  volume       = {386},
  year         = {2015},
}