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Preoperative Quantitative MR Tractography Compared with Visual Tract Evaluation in Patients with Neuropathologically Confirmed Gliomas Grades II and III : A Prospective Cohort Study

Delgado, Anna F; Nilsson, Markus LU ; Latini, Francesco; Mårtensson, Johanna LU ; Zetterling, Maria; Berntsson, Shala G; Alafuzoff, Irina; Lätt, Jimmy LU and Larsson, Elna-Marie LU (2016) In Radiology research and practice 2016(1). p.1-15
Abstract

Background and Purpose. Low-grade gliomas show infiltrative growth in white matter tracts. Diffusion tensor tractography can noninvasively assess white matter tracts. The aim was to preoperatively assess tumor growth in white matter tracts using quantitative MR tractography (3T). The hypothesis was that suspected infiltrated tracts would have altered diffusional properties in infiltrated tract segments compared to noninfiltrated tracts. Materials and Methods. Forty-eight patients with suspected low-grade glioma were included after written informed consent and underwent preoperative diffusion tensor imaging in this prospective review-board approved study. Major white matter tracts in both hemispheres were tracked, segmented, and visually... (More)

Background and Purpose. Low-grade gliomas show infiltrative growth in white matter tracts. Diffusion tensor tractography can noninvasively assess white matter tracts. The aim was to preoperatively assess tumor growth in white matter tracts using quantitative MR tractography (3T). The hypothesis was that suspected infiltrated tracts would have altered diffusional properties in infiltrated tract segments compared to noninfiltrated tracts. Materials and Methods. Forty-eight patients with suspected low-grade glioma were included after written informed consent and underwent preoperative diffusion tensor imaging in this prospective review-board approved study. Major white matter tracts in both hemispheres were tracked, segmented, and visually assessed for tumor involvement in thirty-four patients with gliomas grade II or III (astrocytomas or oligodendrogliomas) on postoperative neuropathological evaluation. Relative fractional anisotropy (rFA) and mean diffusivity (rMD) in tract segments were calculated and compared with visual evaluation and neuropathological diagnosis. Results. Tract segment infiltration on visual evaluation was associated with a lower rFA and high rMD in a majority of evaluated tract segments (89% and 78%, resp.). Grade II and grade III gliomas had similar infiltrating behavior. Conclusion. Quantitative MR tractography corresponds to visual evaluation of suspected tract infiltration. It may be useful for an objective preoperative evaluation of tract segment involvement.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Radiology research and practice
volume
2016
issue
1
pages
1 - 15
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000375303700001
  • scopus:85041545065
ISSN
2090-1941
DOI
10.1155/2016/7671854
language
English
LU publication?
yes
id
75145520-c836-43e1-9403-6c2b12cfcaf6
date added to LUP
2018-01-11 14:05:54
date last changed
2018-05-29 11:03:23
@article{75145520-c836-43e1-9403-6c2b12cfcaf6,
  abstract     = {<p>Background and Purpose. Low-grade gliomas show infiltrative growth in white matter tracts. Diffusion tensor tractography can noninvasively assess white matter tracts. The aim was to preoperatively assess tumor growth in white matter tracts using quantitative MR tractography (3T). The hypothesis was that suspected infiltrated tracts would have altered diffusional properties in infiltrated tract segments compared to noninfiltrated tracts. Materials and Methods. Forty-eight patients with suspected low-grade glioma were included after written informed consent and underwent preoperative diffusion tensor imaging in this prospective review-board approved study. Major white matter tracts in both hemispheres were tracked, segmented, and visually assessed for tumor involvement in thirty-four patients with gliomas grade II or III (astrocytomas or oligodendrogliomas) on postoperative neuropathological evaluation. Relative fractional anisotropy (rFA) and mean diffusivity (rMD) in tract segments were calculated and compared with visual evaluation and neuropathological diagnosis. Results. Tract segment infiltration on visual evaluation was associated with a lower rFA and high rMD in a majority of evaluated tract segments (89% and 78%, resp.). Grade II and grade III gliomas had similar infiltrating behavior. Conclusion. Quantitative MR tractography corresponds to visual evaluation of suspected tract infiltration. It may be useful for an objective preoperative evaluation of tract segment involvement.</p>},
  articleno    = {7671854},
  author       = {Delgado, Anna F and Nilsson, Markus and Latini, Francesco and Mårtensson, Johanna and Zetterling, Maria and Berntsson, Shala G and Alafuzoff, Irina and Lätt, Jimmy and Larsson, Elna-Marie},
  issn         = {2090-1941},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {04},
  number       = {1},
  pages        = {1--15},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Radiology research and practice},
  title        = {Preoperative Quantitative MR Tractography Compared with Visual Tract Evaluation in Patients with Neuropathologically Confirmed Gliomas Grades II and III : A Prospective Cohort Study},
  url          = {http://dx.doi.org/10.1155/2016/7671854},
  volume       = {2016},
  year         = {2016},
}