Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization
(2022) In International Journal of Molecular Sciences 23(7).- Abstract
Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level... (More)
Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level in uterine stromal cells. Progesterone upregulates Caveolin-1 expression in luminal epithelium. During mouse in vitro decidualization, Caveolin-1 is significantly increased. However, Caveolin-1 is obviously decreased during human in vitro decidualization. Caveolin-1 overexpression and siRNA suppress and upregulate IGFBP1 expression under in vitro decidualization, respectively. Blastocysts-derived tumor necrosis factor α (TNFα) and human Chorionic Gonadotropin (hCG) regulate Caveolin-1 in mouse and human decidual cells, respectively. Caveolin-1 levels are also regulated by high glucose and insulin. In conclusion, a low level of Caveolin-1 should be beneficial for human decidualization.
(Less)
- author
- Song, Zhuo ; Li, Bo ; Li, Mengyuan ; Luo, Jiamei ; Hong, Yuqi ; He, Yuying ; Chen, Siting ; Yang, Zhenshan LU ; Liang, Chen and Yang, Zengming
- publishing date
- 2022-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Caveolin-1, decidualization, diabetes, embryo, estrogen, insulin, progesterone, senescence
- in
- International Journal of Molecular Sciences
- volume
- 23
- issue
- 7
- article number
- 3699
- pages
- 20 pages
- publisher
- MDPI AG
- external identifiers
-
- pmid:35409055
- scopus:85127135287
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms23073699
- language
- English
- LU publication?
- no
- additional info
- Funding Information: Funding: This work was funded by National Key Research and Development Program of China [2018YFC1004400] and National Natural Science Foundation of China [31871511 and 31671563]. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- id
- 7552c042-beb6-4df9-90fd-bb3f6a7a80ca
- date added to LUP
- 2024-02-28 15:01:38
- date last changed
- 2024-07-02 21:58:48
@article{7552c042-beb6-4df9-90fd-bb3f6a7a80ca, abstract = {{<p>Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level in uterine stromal cells. Progesterone upregulates Caveolin-1 expression in luminal epithelium. During mouse in vitro decidualization, Caveolin-1 is significantly increased. However, Caveolin-1 is obviously decreased during human in vitro decidualization. Caveolin-1 overexpression and siRNA suppress and upregulate IGFBP1 expression under in vitro decidualization, respectively. Blastocysts-derived tumor necrosis factor α (TNFα) and human Chorionic Gonadotropin (hCG) regulate Caveolin-1 in mouse and human decidual cells, respectively. Caveolin-1 levels are also regulated by high glucose and insulin. In conclusion, a low level of Caveolin-1 should be beneficial for human decidualization.</p>}}, author = {{Song, Zhuo and Li, Bo and Li, Mengyuan and Luo, Jiamei and Hong, Yuqi and He, Yuying and Chen, Siting and Yang, Zhenshan and Liang, Chen and Yang, Zengming}}, issn = {{1661-6596}}, keywords = {{Caveolin-1; decidualization; diabetes; embryo; estrogen; insulin; progesterone; senescence}}, language = {{eng}}, month = {{04}}, number = {{7}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization}}, url = {{http://dx.doi.org/10.3390/ijms23073699}}, doi = {{10.3390/ijms23073699}}, volume = {{23}}, year = {{2022}}, }