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Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization

Song, Zhuo ; Li, Bo ; Li, Mengyuan ; Luo, Jiamei ; Hong, Yuqi ; He, Yuying ; Chen, Siting ; Yang, Zhenshan LU orcid ; Liang, Chen and Yang, Zengming (2022) In International Journal of Molecular Sciences 23(7).
Abstract

Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level... (More)

Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level in uterine stromal cells. Progesterone upregulates Caveolin-1 expression in luminal epithelium. During mouse in vitro decidualization, Caveolin-1 is significantly increased. However, Caveolin-1 is obviously decreased during human in vitro decidualization. Caveolin-1 overexpression and siRNA suppress and upregulate IGFBP1 expression under in vitro decidualization, respectively. Blastocysts-derived tumor necrosis factor α (TNFα) and human Chorionic Gonadotropin (hCG) regulate Caveolin-1 in mouse and human decidual cells, respectively. Caveolin-1 levels are also regulated by high glucose and insulin. In conclusion, a low level of Caveolin-1 should be beneficial for human decidualization.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Caveolin-1, decidualization, diabetes, embryo, estrogen, insulin, progesterone, senescence
in
International Journal of Molecular Sciences
volume
23
issue
7
article number
3699
pages
20 pages
publisher
MDPI AG
external identifiers
  • pmid:35409055
  • scopus:85127135287
ISSN
1661-6596
DOI
10.3390/ijms23073699
language
English
LU publication?
no
additional info
Funding Information: Funding: This work was funded by National Key Research and Development Program of China [2018YFC1004400] and National Natural Science Foundation of China [31871511 and 31671563]. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
id
7552c042-beb6-4df9-90fd-bb3f6a7a80ca
date added to LUP
2024-02-28 15:01:38
date last changed
2024-04-23 16:16:46
@article{7552c042-beb6-4df9-90fd-bb3f6a7a80ca,
  abstract     = {{<p>Decidualization is essential to rodent and primate pregnancy. Senescence is increased during decidualization. Failure of senescence clearance during decidualization will cause pregnancy abnormality. Caveolin-1 is located in plasmalemmal caveolae and involved in senescence. However, whether caveolin-1 is involved in decidualization remains undefined. In this study, we examined the expression, regulation and function of Caveolin-1 during mouse early pregnancy and under mouse and human in vitro decidualization. From days 1 to 8 of pregnancy, Caveolin-1 signals are mainly located in endothelium and myometrium. Estrogen stimulates Caveolin-1 expression in endothelium. Deficiency of estrogen receptor α significantly promotes Caveolin-1 level in uterine stromal cells. Progesterone upregulates Caveolin-1 expression in luminal epithelium. During mouse in vitro decidualization, Caveolin-1 is significantly increased. However, Caveolin-1 is obviously decreased during human in vitro decidualization. Caveolin-1 overexpression and siRNA suppress and upregulate IGFBP1 expression under in vitro decidualization, respectively. Blastocysts-derived tumor necrosis factor α (TNFα) and human Chorionic Gonadotropin (hCG) regulate Caveolin-1 in mouse and human decidual cells, respectively. Caveolin-1 levels are also regulated by high glucose and insulin. In conclusion, a low level of Caveolin-1 should be beneficial for human decidualization.</p>}},
  author       = {{Song, Zhuo and Li, Bo and Li, Mengyuan and Luo, Jiamei and Hong, Yuqi and He, Yuying and Chen, Siting and Yang, Zhenshan and Liang, Chen and Yang, Zengming}},
  issn         = {{1661-6596}},
  keywords     = {{Caveolin-1; decidualization; diabetes; embryo; estrogen; insulin; progesterone; senescence}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{7}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization}},
  url          = {{http://dx.doi.org/10.3390/ijms23073699}},
  doi          = {{10.3390/ijms23073699}},
  volume       = {{23}},
  year         = {{2022}},
}