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Imaging technologies in experimental pulmonary fibrosis research : essential tool for enhanced translational relevance

Belmans, Flore ; Mahmutovic Persson, Irma LU orcid ; Bayat, Sam ; Eaden, James ; Vos, Wim ; Jacob, Joseph ; Chambers, Rachel C. and Vande Velde, Greetje (2025) In European respiratory review : an official journal of the European Respiratory Society 34(177).
Abstract

Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high. This review suggests complementing traditional methods used to evaluate antifibrotic therapies in rodent models, such as histopathological and biochemical markers, and lung function tests, with innovative imaging technologies. These imaging techniques could improve the predictive power and translatability of animal studies in human clinical trials. Notably, previous studies in mice and other rodents have... (More)

Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high. This review suggests complementing traditional methods used to evaluate antifibrotic therapies in rodent models, such as histopathological and biochemical markers, and lung function tests, with innovative imaging technologies. These imaging techniques could improve the predictive power and translatability of animal studies in human clinical trials. Notably, previous studies in mice and other rodents have observed compensatory lung enlargement in response to lung injury, questioning whether the conventional view of pulmonary fibrosis as a restrictive disease applies to rodents. By adding longitudinal image-based biomarkers, we aim to better unravel the complexity of lung responses and facilitate more effective drug development for pulmonary fibrosis, ultimately improving patient outcomes.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European respiratory review : an official journal of the European Respiratory Society
volume
34
issue
177
publisher
European Respiratory Society
external identifiers
  • scopus:105015356954
  • pmid:40903049
ISSN
0905-9180
DOI
10.1183/16000617.0012-2025
language
English
LU publication?
yes
id
755f57dd-835f-406c-8250-64b199e96bf2
date added to LUP
2025-11-10 15:09:49
date last changed
2025-11-11 03:00:01
@article{755f57dd-835f-406c-8250-64b199e96bf2,
  abstract     = {{<p>Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high. This review suggests complementing traditional methods used to evaluate antifibrotic therapies in rodent models, such as histopathological and biochemical markers, and lung function tests, with innovative imaging technologies. These imaging techniques could improve the predictive power and translatability of animal studies in human clinical trials. Notably, previous studies in mice and other rodents have observed compensatory lung enlargement in response to lung injury, questioning whether the conventional view of pulmonary fibrosis as a restrictive disease applies to rodents. By adding longitudinal image-based biomarkers, we aim to better unravel the complexity of lung responses and facilitate more effective drug development for pulmonary fibrosis, ultimately improving patient outcomes.</p>}},
  author       = {{Belmans, Flore and Mahmutovic Persson, Irma and Bayat, Sam and Eaden, James and Vos, Wim and Jacob, Joseph and Chambers, Rachel C. and Vande Velde, Greetje}},
  issn         = {{0905-9180}},
  language     = {{eng}},
  number       = {{177}},
  publisher    = {{European Respiratory Society}},
  series       = {{European respiratory review : an official journal of the European Respiratory Society}},
  title        = {{Imaging technologies in experimental pulmonary fibrosis research : essential tool for enhanced translational relevance}},
  url          = {{http://dx.doi.org/10.1183/16000617.0012-2025}},
  doi          = {{10.1183/16000617.0012-2025}},
  volume       = {{34}},
  year         = {{2025}},
}