Channel current fluctuations conclusively explain neuronal encoding of internal potential into spike trains
(2021) In Physical Review E 103(2).- Abstract
Hodgkin and Huxley's seminal neuron model describes the propagation of voltage spikes in axons, but it cannot explain certain full-neuron features crucial for understanding the neural code. We consider channel current fluctuations in a trisection of the Hodgkin-Huxley model, allowing an analytic-mechanistic explanation of these features and yielding consistently excellent matches with in vivo recordings of cerebellar Purkinje neurons, which we use as model systems. This shows that the neuronal encoding is described conclusively by a soft-thresholding function having just three parameters.
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https://lup.lub.lu.se/record/7579593d-72f2-4184-8e5d-039dfe7b2f4d
- author
- Nilsson, Martin N.P. and Jörntell, Henrik LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Review E
- volume
- 103
- issue
- 2
- article number
- 022407
- publisher
- American Physical Society
- external identifiers
-
- scopus:85101285644
- pmid:33736029
- ISSN
- 2470-0045
- DOI
- 10.1103/PhysRevE.103.022407
- language
- English
- LU publication?
- yes
- id
- 7579593d-72f2-4184-8e5d-039dfe7b2f4d
- date added to LUP
- 2021-03-10 08:20:44
- date last changed
- 2024-06-14 11:09:08
@article{7579593d-72f2-4184-8e5d-039dfe7b2f4d,
abstract = {{<p>Hodgkin and Huxley's seminal neuron model describes the propagation of voltage spikes in axons, but it cannot explain certain full-neuron features crucial for understanding the neural code. We consider channel current fluctuations in a trisection of the Hodgkin-Huxley model, allowing an analytic-mechanistic explanation of these features and yielding consistently excellent matches with in vivo recordings of cerebellar Purkinje neurons, which we use as model systems. This shows that the neuronal encoding is described conclusively by a soft-thresholding function having just three parameters.</p>}},
author = {{Nilsson, Martin N.P. and Jörntell, Henrik}},
issn = {{2470-0045}},
language = {{eng}},
number = {{2}},
publisher = {{American Physical Society}},
series = {{Physical Review E}},
title = {{Channel current fluctuations conclusively explain neuronal encoding of internal potential into spike trains}},
url = {{http://dx.doi.org/10.1103/PhysRevE.103.022407}},
doi = {{10.1103/PhysRevE.103.022407}},
volume = {{103}},
year = {{2021}},
}