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Rapid myelin water imaging in human cervical spinal cord : Myelin Water Imaging in the Cervical Spinal Cord

Ljungberg, Emil LU orcid ; Vavasour, Irene ; Tam, Roger ; Yoo, Youngjin ; Rauscher, Alexander ; Li, David K.b. ; Traboulsee, Anthony ; Mackay, Alex and Kolind, Shannon (2017) In Magnetic Resonance in Medicine 78(4). p.1482-1487
Abstract
Purpose
Myelin water imaging (MWI) using multi-echo T2 relaxation is a quantitative MRI technique that can be used as an in vivo biomarker for myelin in the central nervous system. MWI using a multi-echo spin echo sequence currently takes more than 20 min to acquire eight axial slices (5 mm thickness) in the cervical spinal cord, making spinal cord MWI impractical for implementation in clinical studies.
Methods
In this study, an accelerated gradient and spin echo sequence (GRASE), previously validated for brain MWI, was adapted for spinal cord MWI. Ten healthy volunteers were scanned with the GRASE sequence (acquisition time 8.5 min) and compared with the multi-echo spin echo sequence (acquisition time 23.5... (More)
Purpose
Myelin water imaging (MWI) using multi-echo T2 relaxation is a quantitative MRI technique that can be used as an in vivo biomarker for myelin in the central nervous system. MWI using a multi-echo spin echo sequence currently takes more than 20 min to acquire eight axial slices (5 mm thickness) in the cervical spinal cord, making spinal cord MWI impractical for implementation in clinical studies.
Methods
In this study, an accelerated gradient and spin echo sequence (GRASE), previously validated for brain MWI, was adapted for spinal cord MWI. Ten healthy volunteers were scanned with the GRASE sequence (acquisition time 8.5 min) and compared with the multi-echo spin echo sequence (acquisition time 23.5 min).
Results
Using region of interest analysis, myelin estimates obtained from the two sequences were found to be in good agreement (mean difference = −0.0092, 95% confidence interval =  urn:x-wiley:07403194:media:mrm26551:mrm26551-math-0001 0.0092 ± 0.061; regression slope = 1.01, ρ = 0.9). MWI using GRASE was shown to be highly reproducible with an average coefficient of variation of 6.1%.
Conclusion
The results from this study show that MWI can be performed in the cervical spinal cord in less than 10 min, allowing for practical implementation in multimodal clinical studies. (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
78
issue
4
pages
1482 - 1487
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85001821030
ISSN
1522-2594
DOI
10.1002/mrm.26551
language
English
LU publication?
no
id
75845e97-1abc-416b-9411-b0b3ad6dfb3f
date added to LUP
2023-05-01 08:51:32
date last changed
2023-05-02 08:59:57
@article{75845e97-1abc-416b-9411-b0b3ad6dfb3f,
  abstract     = {{Purpose<br/>Myelin water imaging (MWI) using multi-echo T2 relaxation is a quantitative MRI technique that can be used as an in vivo biomarker for myelin in the central nervous system. MWI using a multi-echo spin echo sequence currently takes more than 20 min to acquire eight axial slices (5 mm thickness) in the cervical spinal cord, making spinal cord MWI impractical for implementation in clinical studies.<br/>Methods<br/>In this study, an accelerated gradient and spin echo sequence (GRASE), previously validated for brain MWI, was adapted for spinal cord MWI. Ten healthy volunteers were scanned with the GRASE sequence (acquisition time 8.5 min) and compared with the multi-echo spin echo sequence (acquisition time 23.5 min).<br/>Results<br/>Using region of interest analysis, myelin estimates obtained from the two sequences were found to be in good agreement (mean difference = −0.0092, 95% confidence interval =  urn:x-wiley:07403194:media:mrm26551:mrm26551-math-0001 0.0092 ± 0.061; regression slope = 1.01, ρ = 0.9). MWI using GRASE was shown to be highly reproducible with an average coefficient of variation of 6.1%.<br/>Conclusion<br/>The results from this study show that MWI can be performed in the cervical spinal cord in less than 10 min, allowing for practical implementation in multimodal clinical studies.}},
  author       = {{Ljungberg, Emil and Vavasour, Irene and Tam, Roger and Yoo, Youngjin and Rauscher, Alexander and Li, David K.b. and Traboulsee, Anthony and Mackay, Alex and Kolind, Shannon}},
  issn         = {{1522-2594}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  pages        = {{1482--1487}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{Rapid myelin water imaging in human cervical spinal cord : Myelin Water Imaging in the Cervical Spinal Cord}},
  url          = {{http://dx.doi.org/10.1002/mrm.26551}},
  doi          = {{10.1002/mrm.26551}},
  volume       = {{78}},
  year         = {{2017}},
}